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MAP3K7 — SMAD3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: MAP3K7 — SMAD3 (in vitro) Liu et al., Proc Natl Acad Sci U S A 1997*
• STRING interaction: SMAD3 — MAP3K7 (interaction, mapped from grid bind kegg_pathways)
• STRING interaction: SMAD3 — MAP3K7 (interaction, mapped from grid bind kegg_pathways)
• STRING interaction: MAP3K7 — SMAD3 (interaction, mapped from grid)
• STRING interaction: MAP3K7 — SMAD3 (interaction, mapped from grid)

Text-mined interactions from Literome

Benus et al., Mol Biol Cell 2005 : IL-1beta and its downstream mediator TAK1 inhibit SMAD3 mediated TGFbeta target gene activation, whereas SMAD3 nuclear translocation and DNA binding in response to TGFbeta are not affected
Gingery et al., Exp Cell Res 2008 : TAK1/MEK activation induces pro-survival BclX ( L ) expression and TAK1/MEK and SMAD pathway activation induces pro-survival Mcl-1 expression
Strippoli et al., PloS one 2012 (Fibrosis...) : Analysis of signalling pathways downstream of TAK1 involved in EMT induction, showed that TAK1 inhibition reduced the transcriptional activity of NF-?B and Smad3 , as well as the phosphorylation of c-jun, while enhancing Smad1-5-8 activity
Yumoto et al., J Biol Chem 2013 (Cleft Palate) : TGF-ß activated Kinase 1 (Tak1) Mediates Agonist induced Smad Activation and Linker Region Phosphorylation in Embryonic Craniofacial Neural Crest derived Cells