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AKT1 — STAT5A
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wheadon et al., Biochem J 2003
:
Expression of WT, C459S and D425A forms of SHP-2 had little effect on IL-3-driven proliferation or
STAT5 ( signal transduction and activators of transcription ) phosphorylation or
activation of
protein kinase B
Versteeg et al., Circ Res 2004
:
Finally, we show that FVIIa leads to cell survival through a
Jak2/STAT5 dependent production of the antiapoptotic STAT5 target Bcl ( XL ) as well as Jak2 dependent activation of the antiapoptotic protein
PKB
Lockyer et al., J Immunol 2007
:
STAT5 is
essential for
Akt/p70S6 kinase activity during IL-2 induced lymphocyte proliferation
Wofford et al., Blood 2008
:
IL-7 promotes Glut1 trafficking and glucose uptake via
STAT5 mediated activation of
Akt to support T-cell survival ... These data demonstrate that IL-7 promotes glucose uptake via a novel signaling mechanism in which
STAT5 transcriptional activity
promotes Akt activation to regulate Glut1 trafficking and glucose uptake that is critical for IL-7 to prevent T-cell death and maintain homeostasis
Creamer et al., Mol Cell Biol 2010
:
The ligand-inducible expression of
Stat5 in transgenic females
mediates a sustained upregulation of
Akt1 in mammary epithelial cells during the onset of postlactational involution
Chen et al., Breast Cancer Res 2010
:
Akt is
required for
Stat5 activation and mammary differentiation
Williams et al., Blood 2012
(Leukemia) :
This aberrant localization was associated with increased
STAT5 activation but
inhibition of both MAPK and
AKT phosphorylation