Nakashima et al., Kidney Int 2000
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JAK1, JAK2, and STAT1 were detected in whole cell lysates, suggesting that JAK-STAT signaling could be activated by interferon-gamma (INF-gamma) You et al., J Biol Chem 1997
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Together, the data suggest that SHP-1 is positively involved in EGF- and INF-gamma induced STAT activation in non-hematopoietic HeLa cells and that, in the EGF signaling system, SHP-1 functions at least partly by modulating tyrosine phosphorylation of EGF receptor