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CNTF — SOAT1
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Schaefer et al., Cell Signal 2000
(Brain Neoplasms) :
Interleukin-6, leukemia inhibitory factor, and
ciliary neurotrophic factor also
induced Stat complexes more selectively and to a lesser magnitude than oncostatin M
Peterson et al., J Neurosci 2000
:
CNTF induced activation of
Jak-STAT signaling prompted us to investigate STAT3 phosphorylation after a variety of stress mediated, conditioning stimuli
Zvonic et al., J Biol Chem 2003
:
In order to investigate the effects of CNTF on fat cells, we examined the expression of CNTF receptor complex proteins ( LIFR, gp130, and CNTFRalpha ) during adipocyte differentiation and the
effects of
CNTF on
STAT , Akt, and MAPK activation
Jiao et al., Brain Res Mol Brain Res 2003
(Neuroblastoma) :
Expression of dominant negative forms of the tyrosine phosphatases, SHP-1 and/or SHP-2, in BE ( 2 ) -C cells had no effect on
CNTF activation of
STAT or on the ability of phosphatase inhibitors to block signaling
Kaur et al., J Neurochem 2005
:
Inducers of oxidative stress block
ciliary neurotrophic factor activation of
Jak/STAT signaling in neurons ... Treatment with hydrogen peroxide ( H ( 2 ) O ( 2 ) ) as a generator of ROS inhibited
CNTF mediated
Jak/STAT signaling in all cultured nerve cells tested, including chick ciliary ganglion neurons, chick neural retina, HMN-1 motor neuron hybrid cells, and SH-SY5Y and BE ( 2 ) -C human neuroblastoma cells
Goureau et al., Dev Neurosci 2004
:
Perturbation of STAT and ERK signaling using protein kinase inhibitors and a dominant negative STAT3 mutant demonstrates that both
CNTF induced
STAT and ERK activation are involved in promoting Muller cell production
Rhee et al., Adv Exp Med Biol 2010
:
CNTF/LIF activates
Jak-STAT , ERK, and Notch pathways during retinal development
Bonni et al., Science 1997
:
Although
CNTF stimulated both the Janus kinase-signal transducer and activator of transcription (
JAK-STAT ) and Ras-mitogen activated protein kinase signaling pathways in cortical precursor cells, the JAK-STAT signaling pathway selectively enhanced differentiation of these precursors along a glial lineage