Rudd et al., J Virol 2005
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Targeting the expression of TLR3 with small interfering RNA decreased synthesis of IP-10/CXCL10 and CCL5 but did not significantly reduce levels of CXCL8 Wang et al., Blood 2008
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We and others have reported that Toll-like receptor ( TLR ) proteins are present on human neutrophils and that granulocyte-macrophage colony stimulating factor ( GM-CSF ) treatment enhances IL-8 ( CXCL8 ) secretion in response to stimulation with TLR ligands
Lee et al., Cell Microbiol 2009
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In addition, TLR2 , Dectin-1 and, to an extent, TLR4 are essential for the MU-mediated expression of CXCL8 , CCL2 and LL-37 in keratinocytes
Sharma et al., J Leukoc Biol 2013
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Our findings reveal a previously unrecognized role for S1P in regulating TLR induced CXCL8 secretion from human T cells