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Shao et al., Cancer Res 2004
(Cell Transformation, Neoplastic...) :
Induction of K-Ras activated PI3K and mTOR in IECs ... p70 ribosomal protein S6 kinase activity was induced by K-Ras in a PI3K- and mTOR dependent manner
Kim et al., Int J Cancer 2013
(Colorectal Neoplasms) :
Taken together, our data suggest that targeting PI3K/MTOR sensitizes cells to apoptosis, implying that activation of PI3K/MTOR signaling via KRAS or PIK3CA mutation is an important pathway in CRC cell growth