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GRAP2 — PIK3CA
Text-mined interactions from Literome
Gonzalez-Robayna et al., Mol Endocrinol 2000
:
Lastly, FSH mediated phosphorylation of
p38MAPK is negatively
affected by A kinase and
PI3-K , suggesting that it may be downstream of specific members of the cAMP-GEF/Rap/Raf pathway
Patel et al., Diabetes 2003
:
None of the inhibitors significantly inhibited protein content over 20 days, but lipid content and lipogenic activity were inhibited by p70 ( S6 ) kinase and
p38 MAPK
inhibition but not by p42/44 MAPK or
PI3K inhibition
Pasapera et al., J Steroid Biochem Mol Biol 2005
:
Transactivation of estrogen-sensitive genes by FSH or PKA activators were blocked ( approximately 90 % ) by H89 ( PKA inhibitor ) and LY294002 but not by Wortmannin (
PI3-K inhibitors ), 4-OH-tamoxifen, ICI182,780 or SB203580 (
p38 MAPK inhibitor ) ; PD98059 ( ERK1/2 inhibitor ) partially ( approximately 30 % ) blocked the FSH mediated effect
Vanni et al., Cell cycle (Georgetown, Tex.) 2006
:
Furthermore, we investigated the signaling molecules involved in proto-Dbl induced cell transformation and motility and observed that inhibition of
PI3K in proto-Dbl expressing cells
induces an increase in
p38 activity and a decrease in ERK phosphorylation
Ruhland et al., Exp Parasitol 2009
:
Interestingly, activation of
PI3K/Akt signaling
had differential effects on ERK and
p38 activation
Kulasekaran et al., Am J Respir Cell Mol Biol 2009
(Idiopathic Pulmonary Fibrosis) :
ET-1 induced activation of
PI3K/AKT is
dependent on
p38 mitogen activated protein kinase ( MAPK ), but not extracellular signal regulated kinase ( ERK ) 1/2, JNK, or transforming growth factor (TGF)-beta1
Dai et al., J Biol Chem 2012
(Carcinoma, Hepatocellular...) :
Both
p38 MAPK promoted glucose regulated protein 78 (GRP78) expression and sustained high basal
activation of
PI3K/Akt and MEK/ERK are involved in the cytoprotective function of p190Met ( NC )
Gao et al., EMBO Mol Med 2012
(Disease Models, Animal...) :
This involved
p38 MAPK
activation by
PI3K to facilitate clathrin mediated ErbB receptor endocytosis
Hsieh et al., Chem Biol Interact 2013
(Breast Neoplasms) :
Additionally, treatment of SB203580 (
p38 MAPK inhibitor ) or wortmannin (
PI3K inhibitor ) resulted in a reduced activity and expression of MMP-2 as well as inhibition on cell migration and invasion in MDA-MB-231 cells