◀ Back to CDH2

CDH2 — EGF

Text-mined interactions from Literome

Diamond et al., J Cell Sci 2008 (Carcinoma, Squamous Cell...) : Unexpectedly, we found that EGF blocked TGFbeta1 mediated N-cadherin expression in oral keratinocytes and not in OSCC cells ... The effect of EGF on TGFbeta1 mediated Smad-driven promoter activity and N-cadherin expression was reversed when activation of ERK1/2 was blocked
Smith et al., American journal of physiology. Renal physiology 2009 : Quantitative RT-PCR and a luciferase reporter assay suggested that sHB-EGF repressed transcription of E-cadherin , and a concomitant TGF-beta independent upregulation of the E-cadherin repressor Snail-2 was observed
Cheng et al., PloS one 2012 (Cystadenocarcinoma, Serous...) : However, EGF induced down-regulation of E-cadherin and concurrent up-regulation of N-cadherin in SBOT cells but not in LGC cells ... The PI3K inhibitor LY294002 had similar effects, but it could not block the EGF induced up-regulation of N-cadherin and ZEB1
Cheng et al., Oncogene 2013 (Ovarian Neoplasms) : These two signaling pathways contribute to the EGF induced downregulation of E-cadherin , which subsequently increases the invasive capability of ovarian cancer cells
Cheng et al., J Clin Endocrinol Metab 2012 : Moreover, the inhibition of EGF induced ERK1/2, p38, and Akt activation by pharmacological inhibitors attenuated EGF induced Slug expression and the down-regulation of E-cadherin , as well as subsequent cell invasion