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IFNB1 — JAK1

Pathways - manually collected, often from reviews:

• BioCarta ifn alpha signaling pathway: IFNAR2/TYK2 complex (TYK2-IFNAR2) → IFN-beta/IFNAR1/IFNAR2/JAK1/TYK2 complex (IFNB1-TYK2-IFNAR2-IFNAR1-JAK1) (modification, collaborate)
  
• BioCarta ifn alpha signaling pathway: IFN-beta (IFNB1) → IFN-beta/IFNAR1/IFNAR2/JAK1/TYK2 complex (IFNB1-TYK2-IFNAR2-IFNAR1-JAK1) (modification, collaborate)
  
• BioCarta ifn alpha signaling pathway: IFN-beta (IFNB1) → IFNAR1/JAK1 complex (IFNAR1-JAK1) (modification, collaborate)
  
• BioCarta ifn alpha signaling pathway: IFN-beta/IFNAR1/IFNAR2/JAK1/TYK2 complex (IFNB1-TYK2-IFNAR2-IFNAR1-JAK1) → IFNAR1/JAK1 complex (IFNAR1-JAK1) (modification, collaborate)
  
• Reactome Reaction: IFNB1 → JAK1 (indirect_complex) You et al., Mol Cell Biol 1999, Chuntharapai et al., J Immunol 1999, Rani et al., J Biol Chem 1999, Mowen et al., Mol Cell Biol 2000, Chill et al., Structure 2003, Lamken et al., J Mol Biol 2004, Gavutis et al., Biophys J 2005, Geiger et al., J Virol 2006, Uzé et al., Curr Top Microbiol Immunol 2007, Xu et al., Frontiers in bioscience : a journal and virtual library 2008, Improta et al., Proc Natl Acad Sci U S A 1994, Müller et al., Nature 1993, Yan et al., EMBO J 1996, Li et al., Mol Cell Biol 1997, Domanski et al., J Biol Chem 1997
• Reactome Reaction: IFNB1 → JAK1 (reaction) Chuntharapai et al., J Immunol 1999, Rani et al., J Biol Chem 1999, Mowen et al., Mol Cell Biol 2000, Chill et al., Structure 2003, Lamken et al., J Mol Biol 2004, Gavutis et al., Biophys J 2005, Geiger et al., J Virol 2006, Uzé et al., Curr Top Microbiol Immunol 2007, Colamonici et al., Mol Cell Biol 1994, Improta et al., Proc Natl Acad Sci U S A 1994, Müller et al., Nature 1993, Yan et al., EMBO J 1996, Gauzzi et al., J Biol Chem 1996, Li et al., Mol Cell Biol 1997, Domanski et al., J Biol Chem 1997

Text-mined interactions from Literome

Nguyen et al., Biochem J 2000 : Here, we report that IFN-alpha/beta and IFN-gamma rapidly activate the JAK-STAT1 ( Janus kinase-signal transducer and activator transcription factor 1 ) and p42/44 mitogen activated protein kinase ( p42/44 MAPK ) in freshly isolated rat hepatocytes
Novick et al., J Interferon Cytokine Res 2000 : The 117.7 mAb, representative of this class of receptor nonblocking mAb, induced hyper-tyrosine phosphorylation of IFNAR-2 in the presence of IFN-alpha/beta but did not inhibit IFN-alpha/beta induced Jak-Stat tyrosine phosphorylation and ISGF3 complex formation
Yokota et al., J Virol 2004 : Although these infected cells did not produce IFN-gamma and suppressed IFN-alpha/beta induced Jak1 phosphorylation, Jak1 was constitutively phosphorylated
Stancato et al., Mol Cell Biol 1997 : The requirement for Jak1 for IFN-beta- and OSM induced activation of Raf-1 was also seen in Jak1-deficient U4A fibrosarcoma cells ... Therefore, it appears that Jak1 is required for Raf-1 activation by both IFN-beta and OSM
Sakamoto et al., Blood 1998 (Leukemia, Myeloid) : Moreover, IFN-gamma induced activation of JAK1 and JAK2 and IFN-beta induced JAK1 and Tyk2 activation were inhibited in NIH-3T3 JAB transformants