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IL2 — LCP2
Text-mined interactions from Literome
Munakata et al., No To Shinkei 1999
(Multiple Sclerosis) :
We studied the
effect of
lymphocytapheresis ( LCP ) on the expanded disability status scale ( EDSS ) clinical score, lymphocyte subsets and
Interleukin-2 (IL-2) production by peripheral blood mononuclear cell ( PBM ) in 5 patients with multiple sclerosis (MS)
Fang et al., J Biol Chem 1999
:
SLP-76 and Vav function in separate, but overlapping pathways to
augment interleukin-2 promoter activity ... Furthermore,
SLP-76 and Vav have a synergistic
effect on
interleukin (IL)-2 promoter activity in T cells ... Surprisingly, we find also that the interaction between
SLP-76 and Vav is not required for their cooperation in
augmenting IL-2 promoter activity, as the two molecules appear to function in different signaling pathways upstream of IL-2 gene expression ... Additionally, overexpression of Vav, but not
SLP-76 ,
augments CD28 induced
IL-2 promoter activity ... These findings suggest that the synergy between
SLP-76 and Vav in
regulating IL-2 gene expression reflects the cooperation between different signaling pathways
Peterson et al., Eur J Immunol 1999
:
IL-2 stimulated
SLP-76 ( -/- ) splenocytes also retain normal antibody dependent cellular cytotoxicity and the ability to secrete IFN-gamma in response to IL-12 stimulation
Di Bartolo et al., J Exp Med 2007
:
Moreover, an
SLP-76-S376A mutant
induced higher
interleukin 2 gene transcription than wild-type SLP-76
Wang et al., Proc Natl Acad Sci U S A 2009
:
LFA-1 enhancement of anti-CD3 induced
IL-2 production was completely
dependent on
SLP-76-ADAP binding
Hussain et al., J Biol Chem 2013
:
Furthermore, the
SLP-76 mediated
induction of
IL-2 and CD69 could be further enhanced by SYK or ZAP-70, but it was independent of their kinase activity
Wu et al., Immunity 1996
(Leukemia, T-Cell) :
Vav and
SLP-76 interact and functionally cooperate in
IL-2 gene
activation
Raab et al., Immunity 1997
:
Therefore, despite effects of Vav-SLP-76 on IL-2 expression,
Vav-SLP-76 binding per se is not
essential for
IL-2 production in all T cells
Musci et al., J Biol Chem 1997
:
Previous work has demonstrated that
SLP-76 , a Grb2 associated tyrosine phosphorylated protein,
augments Interleukin-2 promoter activity when overexpressed in the Jurkat T cell line