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IL2 — ZAP70

Text-mined interactions from Literome

Kim et al., Biochem Biophys Res Commun 2009 : In previous studies, the overexpression of a ZAP-70 mutant ( ZAP-70-Y319F ) inhibited the TcR induced activation of NFAT and IL-2 production, while Hph-1-ctCTLA-4 prevented allergic inflammation ... Hph-1-ZAP-70-Y319F inhibited the phosphorylation of ZAP-70-Tyr319 , LAT-Tyr191, and p44/42 MAPK induced by TcR stimulation, NFAT- and AP-1 mediated gene transcription, and the induction of CD69 expression and IL-2 secretion
Bailey et al., FASEB J 2012 : Finally, after immunization, splenocytes from TgsAPP-a mice displayed decreased levels IFN-?, IL-2 , and IL-4, as well as suppressed ZAP70 activation , after recall antigen stimulation
Chan et al., EMBO J 1995 : Moreover, we demonstrate that phosphorylation of Y493 and activation of ZAP-70 is required for antigen receptor mediated induction of interleukin-2 (IL-2) secretion in lymphocytes
Sancho et al., J Immunol 1993 : Anti-TCR/CD3 stimulation of the TCR/CD3+ J32-3.2 cells resulted in a weak stimulation of both the phosphatidyl inositol and tyrosine kinase signal transduction pathways, as measured by changes in the level of free intracellular calcium, tyrosine phosphorylation of TCR-zeta, CD3-epsilon and ZAP-70 , p56lck, or p59fyn tyrosine kinase activity and IL-2 gene activation