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IL2 — TFRC

Text-mined interactions from Literome

Tchórzewski et al., Med Sci Monit 2005 (Autoimmune Diseases...) : We analyzed reactive oxygen intermediate ( ROI ) production by peripheral blood granulocytes, the production of IL-2 , IL-5, IL-10, IL-12, and TNF-alpha cytokines by lymphocytes, and the activation of CD25, CD26, CD69, CD71 , and HLA DR antigen expression
Poehlmann et al., Am J Reprod Immunol 2006 : Interleukin-2 increases CD71 , STAT3, perforin expression and cytotoxic potential of NK cells
Ruegemer et al., J Immunol 1990 : In contrast, IL-2 stimulated transferrin receptor expression was markedly inhibited by TGF-beta in both T cell lines
von Boehmer et al., Nature 1985 : Binding of antigen to T-cell antigen receptors induces the expression of IL-2 receptors, and binding of IL-2 to these receptors induces transferrin receptor expression and is sufficient to promote the growth of T cells for several days
Shau et al., Cell Immunol 1986 : Similarly, only LGL could be induced by IL-2 to express TfR
Heikkila et al., Nature 1987 : In this way, by blocking the IL-2R with an antibody, it has been demonstrated that IL-2/IL-2R interaction is required to induce TfR expression in activated T cells
Avnstorp et al., Contact Dermatitis 1987 (Dermatitis, Contact) : In contrast, the proportion of cells positive for markers associated with activation ( interleukin-2 receptor ) or proliferation ( transferrin receptor , the Ki-67 nuclear antigen ) of lymphoid cells was found to increase with time in both types of reaction
Neckers et al., Proc Natl Acad Sci U S A 1983 : Our study has revealed that ( i ) monocytes, or a monocyte substitute such as the phorbol ester tetradecanoylphorbol 13-acetate, are required for transferrin receptor expression after mitogen exposure ; ( ii ) the presence of IL-2 receptors is necessary for transferrin receptor induction ; ( iii ) antibody to the IL-2 receptor inhibits thymidine incorporation ( DNA synthesis ) in lymphocytes, but only if administered before transferrin receptors have appeared ; and ( iv ) antitransferrin receptor antibody inhibits DNA synthesis but has minimal effect on IL-2 receptor expression ... Thus, IL-2 receptor induction leads to transferrin receptor induction and subsequent initiation of DNA synthesis
Salmerón et al., J Immunol 1995 (Lymphoma, T-Cell) : Stimulation of the TfR with specific Abs results in T cell proliferation, IL-2 secretion, and protein kinase C activation
Kudoh et al., Int J Cancer 1994 (Carcinoma, Renal Cell...) : Because IL2 binding to its receptor results in TfR expression, the defect in TfR induction in T-TIL appears to be distal to IL2R alpha expression
Seiser et al., J Biol Chem 1993 : Since ferritin expression is known to be modulated by cytokines, we decided to investigate the mechanism by which IL-2 activates TfR gene expression in B6.1 cells
Franklin et al., Clin Immunol Immunopathol 1996 : Measurements of kinase activity in immunoprecipitates of p9O ribosomal S6 kinase ( p90rsk ) demonstrated that stimulation of this cell line with IL-2 also resulted in the activation of p90rsk