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IL2 — STK19
Text-mined interactions from Literome
Maslinski et al., J Biol Chem 1992
:
Stimulation of the
interleukin-2 (IL-2) receptor
results in phosphorylation and activation of cytosolic Raf-1
serine/threonine kinase
Valentine et al., Eur J Immunol 1991
:
The differences in the phosphorylation patterns induced by IL2 and PMA further suggest that more than one kinase can use CD45 as substrate and that
IL2 activates a protein
serine/threonine kinase different from protein kinase C
Amato et al., J Mol Med (Berl) 2009
:
Serum and glucocorticoid regulated kinase 1 ( Sgk1 ) is a
serine-threonine kinase that is
activated by serum, steroids, insulin, vasopressin, and
interleukin 2 at the transcriptional and post-translational levels
Goldstein et al., J Immunol 1993
:
Taken together, our data demonstrate that activation of both a
serine/threonine kinase and a tyrosine kinase is
involved in the
IL-2 , IL-4, and IL-6-stimulation of IgM secretion by SKW6.4 cells and activation of the same or a similar serine/threonine protein kinase is an early step in the signal transduction pathway used by these cytokines