Gene interactions and pathways from curated databases and text-mining

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IL2 — STAT3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Demoulin et al., Cytokines Cell Mol Ther 1998 : IL-2 , IL-7, IL-9 and IL-15 activate STAT3 and STAT5, in contrast to IL-4, which activates STAT6
Gollob et al., J Immunol 1999 : A specific inhibitor of p38 MAP kinase completely inhibits the serine phosphorylation of STAT1 and STAT3 induced by IL-12 and IL-2 and abrogates the functional synergy between IL-12 and IL-2 without affecting STAT tyrosine phosphorylation
Nakamura et al., Oncogene 1999 (Cell Transformation, Viral) : IL-2 induced the DNA binding activity of STAT3 and STAT5 of a HTLV-1 transformed cell line and then stimulated its proliferation
O'Brien et al., J Biol Chem 1999 : STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130 utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone
Eriksen et al., Leukemia 2001 (Sezary Syndrome...) : Constitutive STAT3-activation in Sezary syndrome : tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells ... Moreover, our findings suggest that STAT3 activation might play an important role in the constitutive IL-2Ralpha expression, survival, and growth of malignant SS cells
Campbell et al., J Immunol 2001 (Multiple Myeloma) : Suppression of IL-2 induced T cell proliferation and phosphorylation of STAT3 and STAT5 by tumor derived TGF beta is reversed by IL-15 ... There have been conflicting reports regarding inhibition of IL-2 induced STAT3 and STAT5 phosphorylation by TGFbeta and subsequent suppression of immune responses ... Using TGFbeta producing multiple myeloma tumor cells we demonstrate that tumor derived TGFbeta can block IL-2 induced proliferation and STAT3 and STAT5 phosphorylation in T cells
Lundin Brockdorff et al., Cytokine 2002 (MAP Kinase Signaling System...) : SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells
Owaki et al., J Immunol 2006 : Analyses using various mice lacking a signaling molecule revealed that the inhibition of IL-2 production was dependent on STAT1, but not on STAT3 , STAT4, and T-bet, and was highly correlated with the induction of SOCS3 expression
Poehlmann et al., Am J Reprod Immunol 2006 : Interleukin-2 increases CD71, STAT3 , perforin expression and cytotoxic potential of NK cells ... Interleukin-2R alpha expression is not controlled by sHLA-G1, but its signal transducer STAT3 as well as several downstream effects, such as perforin expression, proliferation and cytotoxicity
Varin et al., Exp Gerontol 2008 : Human peripheral blood mononuclear cells ( PBMC ) were obtained from heparinized blood and were stimulated in vitro by IL-2 or IL-6 for various periods and the phosphorylation of STAT3 and STAT5 was measured by FACScan
Bessoles et al., J Leukoc Biol 2008 (Inflammation) : We demonstrated that IL-2 activates not only STAT3 and -5 and the PI-3K and ERK-2 pathways as in all IL-2 responder cells but also STAT4 as in NK cells and the p38 MAPK pathway as in alphabeta T cells
Sainz-Perez et al., J Immunol 2008 (Leukemia, Lymphocytic, Chronic, B-Cell) : In contrast, IL-24 reversed the IL-2 induced phosphorylation of STAT3 in CLL, and this effect was neutralized by anti-IL-24 Ab. Phospho- ( P ) STAT3 inhibition induced by IL-24 was reversed by pervanadate, an inhibitor of tyrosine phosphatases
Ozawa et al., Journal of ophthalmology 2011 : In innate chorioretinal inflammation, interleukin-6 family ligands induce STAT3 activation in photoreceptors, which causes UPS mediated excessive degradation of the visual substance, rhodopsin
Beadling et al., EMBO J 1994 : IFN alpha activated STAT1, STAT2 and STAT3 in T cells, but no detectable activation of these STATs was induced by IL-2
Bright et al., J Immunol 1997 : We show here that treatment of activated T cells with TGF-beta inhibited IL-2 induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 but not Jak-3 and Stat 3
Ng et al., J Biol Chem 1997 : Our results show that phosphorylation of STAT3alpha on serine 727 is not constitutive in quiescent T cells but can be induced by the cytokine IL-2
Nielsen et al., Cytokine 1998 : It is unknown which Stat3 isoform(s) is activated in response to interleukin (IL)-2 and IL-15 ... In contrast, minimal or no activation of Stat3beta was observed, suggesting that IL-2 and IL-15 predominantly activate Stat3alpha in human CD4 ( + ) T cells
Wang et al., J Immunol 1999 : In both T cells and NK cells, IL-2 induces the activation of STAT1, STAT3 , and STAT5