Schafer et al., J Immunol 1999
:
Inhibitors of p38 also blocked CD4+ T cell production of IL-4 ( SB 203580 IC50 = 20-100 nM ), but not IL-2 , in response to CD3 and CD28 stimulation
Kogkopoulou et al., J Leukoc Biol 2006
:
Furthermore the Erk inhibitor U0126 was able to counteract the effect of p38 inhibition on IL-2 production, supporting the conclusion that p38 mediates its effect through Erk