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IL2 — PTX4

Text-mined interactions from Literome

Nanki et al., Cell Immunol 2001 (MAP Kinase Signaling System) : PTX inhibited the enhancement of IL-2 production and proliferation, whereas anti-CD25 mAb inhibited proliferation, but not IL-2 production
Schneider et al., Infect Immun 2007 : Stimulation of T cells with holotoxin ( PTx ) or the B subunit alone ( PTxB ) rapidly induces signaling events resulting in inositol phosphate accumulation, Ca ( 2+ ) mobilization, interleukin-2 (IL-2) production, and mitogenic cell growth
Alegre et al., Transplantation 1991 : In vitro experiments on human peripheral blood leukocytes indicated that PTX alone or in synergy with methylprednisolone ( m-PDS ) also inhibited the release of TNF and IL-2 induced by OKT3
Rieneck et al., Immunol Lett 1993 : The expression of tumour necrosis factor (TNF)alpha, TNF beta interleukin (IL)-2 and interferon (IFN)gamma was inhibited by PTX in a dose dependent manner, whereas expression of IL-1 alpha, IL-1 beta, and IL-6 was unaffected at concentrations up to 300 microM of PTX
Benbernou et al., J Cardiovasc Pharmacol 1995 : Our findings showed that PTX at the appropriate concentrations could induce selective suppression of IL-2 and IFN-gamma, whereas at high concentrations this drug could act as a suppressive agent of both Th1- and Th2 derived cytokines
Funk et al., Int J Immunopharmacol 1995 : Similarly, PTX and CsA synergistically inhibited the release of IL-2 , IFN-gamma and, to a lesser degree, TNF-alpha
Dong et al., J Clin Immunol 1997 : PTX at a 3.5 x 10 ( -5 ) M concentration significantly inhibited T cell proliferation and the production of tumor necrosis factor-alpha, interleukin-2 , and interleukin-4 ... PTX at a 3.5 x 10 ( -5 ) M concentration significantly inhibited T cell proliferation and the production of tumor necrosis factor-alpha, interleukin-2 , and interleukin-4
Richard et al., Int J Immunopharmacol 1998 : The effects of PTX , RAP, A77 1726, PTX/RAP, or PTX/A77 1726 ( at concentrations approximating the IC50 of individual drugs for inhibition of lymphoproliferation ) on anti-CD3 activated killer ( AK ) cell induction, CD25 expression, and interleukin (IL)-2 synthesis in anti-CD3 activated spleen cell cultures were also determined ... IL-2 synthesis was inhibited by PTX but was unaffected by RAP or A77 1726
Schratzberger et al., Immunopharmacology 1999 : In the present study, we investigated the effects of the anti-inflammatory drug pentoxifylline ( PTX ) on activation of endothelial cells for enhanced adhesion and transmigration of neutrophils by lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1) and granulocyte colony stimulating factor ( G-CSF )