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IL2 — PRF1

Text-mined interactions from Literome

Smyth et al., J Exp Med 1990 : Abrogation of IL-2 induced PFP mRNA expression and cytotoxic potential of T cells by the anti-p75 IL-2 receptor mAb suggested that low numbers of p75 IL-2 receptors on CD8+ T cells were capable of transducing signals responsible for these IL-2 induced effects ... In contrast, high constitutive PFP mRNA expression was observed in CD3- LGL and these mRNA levels could not be enhanced by stimulation with IL-2 ... The cytotoxic potential of peripheral blood T cells and LGL induced in response to IL-2 correlated with IL-2 induced PFP mRNA levels in these cells and was consistent with PFP being one of several important molecules involved in the effector function of cytotoxic lymphocytes
Smyth et al., Cell Immunol 1991 : Clearly, however, both IL-7 and IL-2/IL-7 induced the PFP gene expression and cytotoxic potential of CD8+ T cells and not CD4+ T cells ... By contrast IL-7 or IL-2 augmented the redirected cytotoxic potential of PB gamma delta T cells, but not that of LGL, and neither lymphokine had any effect on constitutive PFP mRNA expression in either lymphocyte subset
Yuan et al., Immunol Lett 2010 : PFP also increased interleukin-2 (IL-2) levels, and decreased the levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in splenocytes
Smyth et al., J Immunol 1990 : Our previous studies have demonstrated that high dose IL-2 ( 1000 U/ml ) alone can induce human peripheral blood T cell pore forming protein (PFP) mRNA expression and cytotoxic potential ... In contrast to the results observed in T cells, IL-6 and IL-2 could enhance CD3- large granular lymphocyte ( LGL ) NK activity, but IL-6 either alone or in combination with IL-2 had no effect on constitutive PFP mRNA expression in resting LGL