Gene interactions and pathways from curated databases and text-mining

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IL2 — MAPK3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Varga et al., Int Immunol 1999 : Suppression of activation of both MEK and p38 MAPK resulted in significant inhibition of IL-2 gene expression
Gadina et al., J Biol Chem 2000 : We previously identified SHP-2 ( Src homology 2 domain containing phosphatase 2 ) as an important intermediate in IL-2 dependent MAPK activation and showed its association with a 98-kDa phosphoprotein in response to IL-2
Wei et al., Immunobiology 2000 : IL-2 induces the association of IL-2Rbeta, lyn, and MAP kinase ERK-1 in human neutrophils
McDermott et al., J Biol Chem 2002 : Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1
Ling et al., Crit Care Med 2002 : In contrast to its effects on the janus kinase/STAT pathways, interleukin-6 activation of MAP kinases ( extracellular signal regulated kinase-1 , extracellular signal regulated kinase-2, and p38 ) was unaffected by endotoxin
Irusen et al., J Allergy Clin Immunol 2002 (Asthma) : Activation of p38 MAPK by IL-2 and IL-4, as shown by means of phosphorylation of activated transcription factor 2, resulted in GR phosphorylation and reduced dexamethasone repression of LPS stimulated GM-CSF release
Yan et al., J Biol Chem 2002 : This model probiotic also inhibits activation of the pro-apoptotic p38/mitogen activated protein kinase by tumor necrosis factor, interleukin-1alpha , or gamma-interferon
Kovanen et al., J Biol Chem 2003 (MAP Kinase Signaling System) : In IL-2 dependent CTLL-2 cells, we show that IL-2 induced ERK-1/2 activity was inhibited by wild type DUSP5 but markedly increased by an inactive form of DUSP5, suggesting a negative feedback role for DUSP5 in IL-2 signaling
Jee et al., J Invest Dermatol 2002 (Carcinoma, Basal Cell...) : Next, interleukin-6 stimulation elicited extracellular signal regulated kinase activation in basal cell carcinoma cells, and the mitogen activated protein kinase inhibitor, PD98059, could affect this response without affecting the interleukin-6-medi ated Mcl-1 upregulation
Ruhul Amin et al., Oncogene 2002 : In addition, PP1 substantially inhibited the IL-2beta- and TNFalpha dependent activation of Erk 1/2 and Akt
García-Lora et al., Cancer Immunol Immunother 2003 : Different regulation of PKC isoenzymes and MAPK by PSK and IL-2 in the proliferative and cytotoxic activities of the NKL human natural killer cell line
Lundin Brockdorff et al., Cytokine 2002 (MAP Kinase Signaling System...) : SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells ... The cells transfected with inactive SHP2 showed reduced MAPK activation upon IL-2 stimulation, suggesting that SHP2 upregulates IL-2 induced MAPK activation in T cells ... In conclusion, we show for the first time that SHP2 positively regulates IL-2 induced MAPK activation in malignant T cells
Faubert Kaplan et al., Int Immunopharmacol 2003 : Collectively, these studies suggest that cannabinoid induced inhibition of IL-2 in PMA/Io stimulated splenocytes might be due , in part, to inhibition of ERK MAPK activation
Kotturi et al., J Biol Chem 2003 : We found that treatment of T lymphocytes with ( +/- ) Bay K 8644 increased intracellular Ca2+ and induced the activation of phosphoextracellular regulated kinase 1/2 ( Erk1/2 ), whereas nifedipine blocked Ca2+ influx, the activity of Erk1/2 and nuclear factor of activated T cells ( NFAT ), interleukin-2 (IL-2) production, and IL-2 receptor expression
Veiopoulou et al., Neuroimmunomodulation 2004 (MAP Kinase Signaling System) : Here we have examined the role of p38 MAPK on IL-2 and IL-10 production following activation of human CD4+ T cells or of the leukemic cell line Hut-78, with either plate bound anti-CD3 in the presence or absence of soluble anti-CD28 ( plCD3, plCD3/sCD28 ), or with cross linked anti-CD3 and anti-CD28 ( crsCD3+CD28 ), or with PMA plus ionomycin
Mason et al., Infect Immun 2004 : TRAF6 dependent mitogen activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii
Fang et al., J Immunol 2005 (Calcium Signaling...) : Anthrax lethal toxin blocks MAPK kinase dependent IL-2 production in CD4+ T cells
Dillon et al., Mol Cell Biol 2005 : The mitogen activated protein kinase extracellular signal regulated kinase ( ERK ) is activated following engagement of the T-cell receptor and is required for interleukin 2 (IL-2) production and T-cell proliferation
Yang et al., Clin Exp Immunol 2006 (MAP Kinase Signaling System...) : Differential regulation of interleukin-12 and tumour necrosis factor-alpha by phosphatidylinositol 3-kinase and ERK 1/2 pathways during Mycobacterium tuberculosis infection
Kogkopoulou et al., J Leukoc Biol 2006 : Conditional up-regulation of IL-2 production by p38 MAPK inactivation is mediated by increased Erk1/2 activity
Molinero et al., Hum Immunol 2006 : IL-2 effect involved Jak3/STAT5, p38 MAPK , p70 ( 56 ) kinase, Lck/fyn kinases, and NF-kappaB
Suzuki et al., Cytokine 2008 (Hemorrhage...) : Two hours thereafter, T cell production of IL-2 and IFN-gamma and activation of MAPK ( p38, ERK-1/2 and JNK ) were determined
Hamdi et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : As a functional consequence of this PLD2 dependent MAPK activation, interleukin-2 production evoked by PMA/ionomycin stimulation or CD3/CD28 engagement was enhanced in the two T-cell lines overexpressing PLD2 ... As a functional consequence of this PLD2 dependent MAPK activation, interleukin-2 production evoked by PMA/ionomycin stimulation or CD3/CD28 engagement was enhanced in the two T-cell lines overexpressing PLD2
Kovanen et al., J Biol Chem 2008 (MAP Kinase Signaling System) : IL-2 activates mitogen activated protein kinase ( MAPK ), phosphatidylinositol 3-kinase, and signal transducer and activator of transcription ( STAT ) pathways and modulates expression of target genes
Kim et al., Biochem Biophys Res Commun 2009 : Hph-1-ZAP-70-Y319F inhibited the phosphorylation of ZAP-70-Tyr319, LAT-Tyr191, and p44/42 MAPK induced by TcR stimulation, NFAT- and AP-1 mediated gene transcription, and the induction of CD69 expression and IL-2 secretion
Conrad et al., Cell Signal 2009 : Collectively, these results suggest that during Thy-1 induced T-lymphocyte activation, ERK1/2 and JNK promoted IL-2 production whereas p38 MAPK negatively regulated IL-2 expression ... Collectively, these results suggest that during Thy-1 induced T-lymphocyte activation, ERK1/2 and JNK promoted IL-2 production whereas p38 MAPK negatively regulated IL-2 expression ... IL-2R signalling involved both p38 MAPK and JNK in CTLL-2 cells, whereas p38 MAPK was most important for IL-2R signalling in primary T-lymphocytes
Yu et al., Am J Physiol Cell Physiol 2010 : Previous research has shown that shockwave treatment affects T-cell function, enhancing T-cell proliferation and IL-2 expression by activating p38 mitogen activated protein kinase ( MAPK ) signaling
Munitz et al., Gastroenterology 2010 (Colitis...) : In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6, interleukin-1beta , and tumor necrosis factor alpha ) and activation of MAPK and NF-kappaB in Pirb-/- macrophages following bacterial activation
Glossop et al., J Tissue Eng Regen Med 2010 : In a previous gene expression study, we reported a potentially important role for mitogen activated protein kinase kinase kinase 8 ( MAP3K8 ) and interleukin-1ß ( IL-1B ) in MAPK signalling in MSCs exposed to fluid shear stress
Woehrle et al., J Leukoc Biol 2010 : Blocking or silencing of Panx1 or of P2X1, P2X4, or P2X7 receptors blunts HS-induced p38 MAPK activation and the stimulatory effects of HS on TCR/CD28 induced IL-2 gene transcription
Rasheed et al., Arthritis Res Ther 2010 (Osteoarthritis) : Pomegranate extract inhibits the interleukin-1ß induced activation of MKK-3, p38a-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
Dauphinee et al., Am J Physiol Heart Circ Physiol 2011 : We find that Ga ( i/o ) -mediated activation of the MAPK is independent of the canonical MyD88, interleukin-1 receptor associated kinase, and tumor necrosis factor receptor associated factor 6 signaling cascade in LPS stimulated cells
Byun et al., Biochem Biophys Res Commun 2012 (Inflammation) : In addition, EGCG treated DCs inhibited lipopolysaccharide (LPS) induced production of pro-inflammatory cytokines ( tumor necrosis factor [TNF ] -a, interleukin [ IL]-1ß, and IL-6 ) and activation of mitogen activated protein kinases ( MAPKs ), e.g., extracellular signal regulated kinase 1/2 ( ERK1/2 ), p38, c-Jun N-terminal kinase (JNK), and nuclear factor ?B ( NF-?B ) p65 translocation through 67LR
Tormos et al., Hepatology 2013 (Chronic Disease...) : p38a mitogen activated protein kinases ( MAPK ) may be essential in the up-regulation of proinflammatory cytokines and can be activated by transforming growth factor ß, tumor necrosis factor-a, interleukin-1ß , and oxidative stress
Fairhurst et al., Immunology 1993 : Activation of mitogen activated protein kinase/ERK-2 in phytohaemagglutin in blasts by recombinant interleukin-2 : contrasting features with CD3 activation
Franklin et al., Clin Immunol Immunopathol 1996 : Activation of p42erk2 MAPK and p90rsk by IL-2 occurs independently of protein kinase C ... Stimulation of the human interleukin-2 (IL-2) dependent cell line, Kit225, with IL-2 resulted in the rapid activation of microtubule associated protein-2 kinase ( MAPK ), as demonstrated by the tyrosine phosphorylation of p42erk2, the reduced mobility of MAPK in SDS-PAGE gels, and the increased ability of lysates from these cells to phosphorylate myelin basic protein ... Stimulation of the human interleukin-2 (IL-2) dependent cell line, Kit225, with IL-2 resulted in the rapid activation of microtubule associated protein-2 kinase ( MAPK ), as demonstrated by the tyrosine phosphorylation of p42erk2, the reduced mobility of MAPK in SDS-PAGE gels, and the increased ability of lysates from these cells to phosphorylate myelin basic protein ... These results demonstrate that IL-2 stimulation results in the activation of MAPK and p90rsk and that this activation occurs in a PKC independent manner
Rao et al., Cell Growth Differ 1995 (Lymphoma, T-Cell) : Rapid activation of mitogen activated protein kinase and p21ras by prolactin and interleukin 2 in rat Nb2 node lymphoma cells
Pahlavani et al., Frontiers in bioscience : a journal and virtual library 1998 : In addition, preliminary results suggest that activation of the upstream signaling molecules, the mitogen activated protein kinase ( MAPK ) signaling cascade, may play a role in the enhancement of IL-2 transcription
Gadina et al., J Immunol 1998 : Finally, SHP-2 expression amplified STAT dependent transcriptional activation whereas a dominant negative allele inhibited transactivation and the IL-2 induced activation of MAPK ( mitogen activated protein kinase )
Kirk et al., Cell Immunol 1998 : Stimulation of the ERK ( MAPK ) pathway in T-lymphocytes contributes to cell activation and IL-2 production