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IL2 — ITGAE

Text-mined interactions from Literome

Sigmundsdóttir et al., Clin Immunol 2004 : Differential effects of interleukin 12 and interleukin 10 on superantigen induced expression of cutaneous lymphocyte associated antigen ( CLA ) and alphaEbeta7 integrin ( CD103 ) by CD8+ T cells
Sharma et al., J Immunol 2009 (Inflammation) : IL-2 regulates CD103 expression on CD4+ T cells in Scurfy mice that display both CD103 dependent and independent inflammation ... CD103 ( + ) CD4 ( + ) T cells, but not CD8 ( + ) T cells or CD11c ( + ) dendritic cells, were significantly up-regulated only in Sf mice, indicating Il2 ( -/- ) dominantly and specifically inhibited CD103 up-regulation in Sf CD4 ( + ) T cells ... The data indicate that IL-2 is required for optimal CD103 induction on CD4 ( + ) T cells in Sf mice and this effect contributes to inflammation in an organ-specific manner
Gunnlaugsdottir et al., Scand J Immunol 2013 : The aim of this study was to define the regulatory role of IL-2 and TGF-ß1 on the CD103 expression and the optimal in vitro conditions for the induction/expansion of human CD4 ( + ) and CD8 ( + ) Tregs ... TGF-ß1 and IL-2 were both required for optimal expression of CD103 ... In addition, TGF-ß1 and IL-2 synergistically induced CD103 expression on CD8 ( + ) T cells, whereas, only additive induced expression was noted on CD4 ( + ) T cells ... IL-2 also played a central role in CD103 expression by CD25 ( hi ) Foxp3+ Tregs