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CD58 — IL2

Text-mined interactions from Literome

Trifiletti et al., Cell Immunol 1989 : Since in other experimental systems the activation of T cells by CD2/LFA-3 interactions has resulted in increased secretion of interleukin 2 (IL2) , we were interested in studying the role of IL2 in PBMC cultures stimulated with PWM and autologous E
Parra et al., J Immunol 1995 (Leukemia-Lymphoma, Adult T-Cell) : We now demonstrate that B7, but not LFA-3 , strongly costimulated IL-2 transcription and mRNA expression in CD4+ T cells ... Maximal increase in IL-2 transcription was recorded with CHO-DR/B7/LFA-3, suggesting a cooperative effect of B7 and LFA-3 at the transcriptional level ... These may partly account for the differential effects of B7 and LFA-3 costimulation on IL-2 expression
Mäenpää et al., Int J Cancer 1993 : CD2, CD44, CD54 and CD58 were increased by IL-2 but L-selectin was strongly down-regulated on the long-term activated NK cells
Parra et al., Mol Cell Biol 1997 : Combined B7-1-LFA-3 costimulation resulted in a synergistic increase in IL-2 transcriptional activity ... This selectivity may contribute to regulation of the levels of IL-2 induced by LFA-3 and B7-1 costimulation and favor autocrine and paracrine T-cell responses, respectively