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CD40 — IL2

Text-mined interactions from Literome

Bartholomé et al., J Interferon Cytokine Res 1999 : IFN-beta interferes with the differentiation of dendritic cells from peripheral blood mononuclear cells : selective inhibition of CD40 dependent interleukin-12 secretion
Kitagawa et al., Arthritis Rheum 1999 (Arthritis, Rheumatoid) : Differential regulation of rheumatoid synovial cell interleukin-12 production by tumor necrosis factor alpha and CD40 signals
Muraille et al., Blood 1999 : Anti-CD3epsilon treatment was found to induce a selective deficiency in the ability of spleen cells to produce bioactive interleukin-12 in response to CD40 stimulation
Dahlenborg et al., Immunology 2000 : Cells were first cultured in the presence of CD32L cell transfectants and CD40 antibody ( the ` CD40 system ' ) supplemented with combinations of cytokines capable of supporting similar levels of CD40 dependent GC B-cell growth [interleukin (IL)-10 + IL-1beta + IL-2 and IL-10 + IL-7 + IL-4 ]
Schultze et al., Br J Haematol 2001 (Leukemia, Plasma Cell) : A pilot study of combined immunotherapy with autologous adoptive tumour-specific T-cell transfer, vaccination with CD40 activated malignant B cells and interleukin 2
Agematsu et al., Clin Immunol 2002 (Common Variable Immunodeficiency) : B cells from CVID patients produced IgM and IgG, but not IgA upon the engagement of Ig receptor and CD40 in the presence of IL-2 and IL-10
Cattaruzza et al., J Biol Chem 2003 : Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40 mediated interleukin-12 synthesis in human endothelial cells
Melichar et al., Int J Gynecol Cancer 2003 (Carcinoma...) : Soluble CD40Lt did not enhance MO/MA cytotoxic activity, and inhibited IFN-gamma or IL-2 induced cytoxicity
Néron et al., Immunology 2005 : Proliferation and differentiation of B lymphocytes were monitored in response to graded levels of CD40 stimulation in the presence of interleukin (IL)-2 , IL-4 and IL-10
Pinzon-Charry et al., Neoplasia (New York, N.Y.) 2005 (Adenocarcinoma...) : Importantly, despite DR ( + ) IC 's poor responsiveness to inflammatory factors, in samples from healthy volunteers and breast cancer patients, CD40 ligation induced phenotypic maturation and interleukin 12 secretion, in turn generating more efficient T-cell responses
Masunaga et al., Transplantation 2005 : Dimeric soluble CD40Ig did not inhibit CD4 T cell proliferation but rather promoted IL-2 production and the generation of CD4CD25 T cells, which regulated alloantigen-specific cytotoxic T lymphocyte activity
Danese et al., Gut 2007 (Colitis...) : Engagement of CD40 on HIFs promoted the release of vascular endothelial growth factor ( VEGF ), interleukin-8 (IL-8) and hepatocyte growth factor (HGF)
Reyes-Moreno et al., J Biol Chem 2007 : Stimulation of CD154 positive T cells with staphylococcal enterotoxin E superantigen that mimics nominal antigen in initiating cognate T cell/APC interaction revealed that dl-CD40 homodimer formation is required for interleukin-2 production by T cells
Bose et al., Hum Immunol 2007 (Carcinoma, Squamous Cell...) : Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L mediated endogenous production of interleukin-12
Bihl et al., J Immunol 2010 (Leishmaniasis, Cutaneous) : We show that early IFN-gamma secretion by NK cells is controlled by IL-2 and IL-12 and is dependent on CD40/CD40L interaction
Benslimane et al., PloS one 2012 : We also found that CD154-chimera lost the ability to promote IL-2 production upon T cell stimulation with anti-CD3/CD28 and soluble CD40
Vallé et al., Eur J Immunol 1989 : In this respect, anti-CD40 does not induce a significant increase of B cell surface IL 4 receptors while IL 4, but not IL 2 , induces a twofold increase of the CD40 antigen expression
Poudrier et al., J Exp Med 1994 : By contrast CD40 ligation, which induced B cell proliferation, did not induce IL-2 responsiveness
Burdin et al., J Immunol 1995 : First, both CD40 and Ag receptor ( AgR ) cross linking induced purified tonsillar human B lymphocytes to secrete the same pattern of cytokines, including IL-1 beta, IL-6, IL-10, granulocyte-macrophage-CSF, and TNF-alpha, whereas IL-1 alpha, IL-2 , IL-3, IL-4, IL-5, IL-7, granulocyte (G)-CSF, or IFN-gamma were not detected
Kennedy et al., Eur J Immunol 1996 : CD40/CD40 ligand interactions are required for T cell dependent production of interleukin-12 by mouse macrophages
Cella et al., J Exp Med 1996 : Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity : T-T help via APC activation
Peng et al., Eur J Immunol 1996 : In this study we demonstrate that upon stimulation of human peripheral blood T cells through the T cell receptor (TCR)/CD3 complex, CD40/CD40L interaction strongly enhances the production of Th1 cytokines such as interleukin (IL)-2 and interferon (IFN)-gamma and Th2 cytokines such as IL-4, IL-5 and IL-10 by a direct effect on T cells ... In this study we demonstrate that upon stimulation of human peripheral blood T cells through the T cell receptor (TCR)/CD3 complex, CD40/CD40L interaction strongly enhances the production of Th1 cytokines such as interleukin (IL)-2 and interferon (IFN)-gamma and Th2 cytokines such as IL-4, IL-5 and IL-10 by a direct effect on T cells
Söderberg et al., Scand J Immunol 1997 (Leukemia, Lymphocytic, Chronic, B-Cell) : CD40 ligation inhibits IL-2 and SAC+IL-2 induced proliferation in chronic lymphocytic leukaemia cells ... In addition, we also found that IL-2+Trx and SAC+IL-2+Trx induced DNA synthesis of B-CLL cells was inhibited by CD40 activation ( by soluble anti-CD40 MoAb and anti-CD40 MoAb presented on irradiated CD32L cells ) ... In clear contrast, SAC+IL-2+ Trx induced DNA synthesis of normal B cells was not inhibited by soluble anti-CD40 MoAb
Ravanel et al., J Exp Med 1997 (Measles) : Finally, the in vitro Ig synthesis of CD40- or Ig-activated human B lymphocytes in the presence of interleukin (IL)-2 and IL-10 was reduced by 50 % in the presence of recombinant NP
Yoshimoto et al., Eur J Immunol 1997 : Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappaB
Séguin et al., J Infect Dis 1999 : Sensitized lymphocytes and CD40 ligation augment interleukin-12 production by human dendritic cells in response to Toxoplasma gondii