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CBL — IL2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Chorba et al., Blood 1985
:
CM cell cultures and the transformed
CBL do not
require exogenous
interleukin 2 , have T cell cytochemical features and mature T helper phenotypes, and exhibit minimal T helper and profound T suppressor activity on pokeweed mitogen stimulated differentiation of normal B cells
Nair et al., Cell Immunol 1985
:
Although the NK activity of
CBL was not
stimulated by either IFN or
IL-2 to the same levels shown by a-PBL, the percentage enhancement of cytotoxicity of CBL by IFN and IL-2 was greater than that of a-PBL
Gesbert et al., J Biol Chem 1998
:
Interleukin-2 stimulation
induces tyrosine phosphorylation of
p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells ... Furthermore,
IL-2 stimulation
increased the level of interaction of phosphorylated
Cbl with the p85 SH2 domains, and we provide evidence that the preformed Cbl-Grb2 complex recruits the phosphorylated p52 Shc adaptor protein