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AKT2 — GRK5
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kurose et al., Nihon Yakurigaku Zasshi 1999
(Myocardial Reperfusion Injury) :
Expression of
GRK2-ct inhibited the H2O2 induced activation of ERK by 70 % and also
inhibited the activation of
Akt by 30 %
Liu et al., Nat Med 2005
(Hypertension, Portal) :
Furthermore,
GRK2 expression increased in sinusoidal endothelial cells from portal hypertensive rats and knockdown of GRK2
restored Akt phosphorylation and NO production, and normalized portal pressure
Zhou et al., Clinical and translational science 2009
:
GRK5 overexpression in HCAECs significantly
suppressed both acute and late activation of
Akt and extracellular signal related kinase ( ERKs ) as well as the phosphorylation of GSK-3beta, an endogenous substrate of Akt
Zheng et al., Proc Natl Acad Sci U S A 2012
:
By suppressing GRK expression with siRNA, we demonstrated that lowering GRK5/6 abolishes IGF1 mediated ERK and
AKT activation, whereas
GRK2 inhibition
increases ERK activation and partially inhibits AKT signaling