Gene interactions and pathways from curated databases and text-mining

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CASP8 — FASLG

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Gregory et al., Immunol Rev 2000 (Listeriosis) : Evidence demonstrating the perforin- and/or Fas ligand dependent induction of caspase activity and the resultant apoptosis of Listeria infected hepatocytes is discussed
Reynaud et al., Mol Cell Endocrinol 2000 : Fas ligand binding on oocytic fas may result in caspase 8 activation
Berglund et al., J Mol Biol 2000 : The properties of the FADD-DD structure are discussed with respect to previously reported mutagenesis data and emerging models for FasL induced FADD recruitment to Fas and caspase-8 activation
Yamamoto et al., Eur J Cancer 2000 (Carcinoma, Squamous Cell...) : These results indicate that anticancer drugs and gamma-rays prime squamous cell carcinoma cells to be susceptible to apoptosis by LAK cells, that LAK cell induced apoptosis largely depends on the activation of caspase-3 by the Fas/Fas-ligand signal and granzyme B, and that LAK cells induce ROI in the target cells, which is largely mediated by Fas and granzyme B
Schlapbach et al., Eur J Immunol 2000 : The presence of FLIP strongly interfered with FasL induced activation of caspase-8 and caspase-3 preventing subsequent cell death
Cuvillier et al., Cell Death Differ 2001 (Adenocarcinoma...) : Furthermore, neither doxorubicin nor sphingosine treatment affected expression of Fas ligand or induced activation of the apical caspase-8 , indicating a Fas/Fas ligand independent mechanism
Kim et al., Immunopharmacol Immunotoxicol 2001 : Gamma-interferon ( IFN-gamma ) augments apoptotic response to mistletoe lectin-II via upregulation of Fas/Fas L expression and caspase activation in human myeloid U937 cells
Siegmund et al., J Biol Chem 2001 : Fas associated death domain protein ( FADD ) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) via a FLICE inhibitory protein (FLIP) regulated pathway ... FasL- and TRAIL mediated up-regulation of c-Fos was completely dependent on the presence of Fas associated death domain protein ( FADD ) and caspase-8 , but caspase activity seemed to be dispensable as a pan inhibitor of caspases had no inhibitory effect
Knight et al., Oncogene 2001 (Glioma) : Our findings indicate that FADD and Caspase-8 are essential for FasL and TRAIL mediated apoptosis in glioma cells
Suhara et al., Mol Cell Biol 2002 : Diminished Akt signaling promoted the cleavage of caspase 3, and both caspase 3 cleavage and FasL induction were inhibited by transduction of dominant negative caspase 9 or the caspase 8 inhibitor CrmA ... Similarly, induction of FasL by the Akt regulated forkhead transcription factor FKHRL1 was dependent upon caspase and c-Jun activation
Langelier et al., J Gen Virol 2002 : Activation of caspase-8 induced either by TNF or by Fas ligand expression was prevented by the R1 protein
Chung et al., Blood 2003 : SCF ( 100 ng/mL ) clearly inhibited the activation of caspase-8 and caspase-3 induced by IFNgamma and/or FasL , and it also reduced apoptosis as measured by the terminal dUTP nick-end labeling ( TUNEL ) assay
Puviani et al., J Invest Dermatol 2003 (Pemphigus) : Fas ligand in pemphigus sera induces keratinocyte apoptosis through the activation of caspase-8
Mueller et al., Cancer Res 2003 (Testicular Neoplasms) : Failure of caspase-9 activation and cisplatin resistance was independent of the expression of p53, Bcl-2 family proteins, Fas receptor, and Fas ligand
Mauriz et al., Shock 2003 (Necrosis...) : Fas ligand expression was markedly elevated and caspase-3 activity increased by 3-fold in hemorrhagic untreated rats
Lee et al., J Immunol 2003 : Inhibition of TCR induced CD8 T cell death by IL-12 : regulation of Fas ligand and cellular FLIP expression and caspase activation by IL-12
Date et al., J Mol Cell Cardiol 2003 (Anoxia...) : We demonstrated that in neonatal rat cardiomyocytes maintained under normal culture conditions, recombinant human soluble FasL increased caspase 3 activation by twofold but did not reduce cell viability
Curtin et al., Cell Signal 2003 : Activation of Fas receptor by Fas ligand causes caspase 8 activation and apoptosis in cells and is an important mechanism by which normal tissue homeostasis and function are maintained
Lambert et al., Int J Cancer 2004 (Sarcoma, Experimental) : In addition, 2-methoxyestradiol treatment caused upregulation of death receptor ligands FasL and TNFalpha and induced caspase-8 activation
Yang et al., J Gastrointest Surg 2004 (Liver Diseases) : FasL induces hepatocyte injury and death and upregulates p38-MAPK and caspase-3 within hepatocytes
Juang et al., J Interferon Cytokine Res 2004 (Adenocarcinoma...) : After HuIFN-beta exposure, COH and CC-M2 cells showed increased levels of Fas and FasL proteins, alteration of mitochondrial membrane potential, and activation of caspase-9 , caspase-8, and caspase-3 in a time dependent manner
Taylor et al., Mol Hum Reprod 2004 (Infertility, Male) : Staurosporine, but not a Fas ligand or H2O2, significantly increased caspase activity, but only in high motility fractions
Huang et al., Eur J Pharmacol 2004 (Prostatic Neoplasms) : Caseamembrin C also induced the up-regulation of Fas ligand (FasL) expression, cleavage and activation of caspase-8 and caspase-9, Bid cleavage and activation of executor caspase-3
Misseri et al., American journal of physiology. Renal physiology 2005 (Inflammation...) : Renal obstruction induced increased tissue TNF-alpha and Fas ligand mRNA levels, TNF-alpha protein production, apoptotic renal tubular cell death, and elevated caspase 8 and 3 activity, whereas treatment with PEG-sTNFR1 significantly reduced obstruction induced TNF-alpha production, renal tubular cell apoptosis, and caspase activity
Wang et al., Mol Cell Biol 2004 : The pX-dependent expression of Fas/FasL and TNFR1/TNF-alpha mediates caspase 8 activation, resulting in Bid cleavage
Hsu et al., J Pharmacol Exp Ther 2005 (Breast Neoplasms) : Asiatic acid treatment triggered the mitochondrial apoptotic pathway indicated by changing Bax/Bcl-2 ratios, cytochrome c release, and caspase-9 activation, but it did not act on Fas/Fas ligand pathways and the activation of caspase-8
Wang et al., Transplant Proc 2004 (Liver Failure, Acute) : Recombinant FasL produced a dose dependent increase in TUNEL positive percentage and caspase-3 activity in uninfected hepatocytes, but did not influence these features in AdCMVhBcl-2 infected cells
Hauptschein et al., Cancer Res 2005 (Carcinoma, Renal Cell...) : FALI of the Fas receptor ( Fas/CD95 ) using a fluorescein conjugated anti-Fas antibody abrogated Fas ligand mediated caspase activation
Chaturvedi et al., Int J Oncol 2005 : Our results showed that ( i ) treatment with FasL increased caspase-8 activity ( maximum at 4 h ) and apoptosis ( maximum at 8 h ) in both MUC1 ( + ) and MUC1 ( - ) cells, ( ii ) FasL induced caspase-8 activity and apoptosis were significantly greater in MUC1 ( + ) cells compared with MUC1 ( - ) cells, ( iii ) FasL treatment increased cell surface expression of Fas receptor in MUC1 ( + ) cells to a greater extent compared with MUC1 ( - ) cells, ( iv ) increased cell surface expression of Fas in MUC1 ( + ) cells was not blocked by an inhibitor of protein synthesis ( cycloheximide ), but was completely abrogated by brefeldin A, an inhibitor of post-translational protein trafficking to the cell surface, and ( v ) brefeldin A inhibited the increased sensitivity of MUC1 ( + ) cells to FasL induced apoptosis
Hougardy et al., Gynecol Oncol 2005 (Papillomavirus Infections...) : Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor Fas can activate a caspase-cascade resulting in apoptosis
Beier et al., J Neurosci 2005 (Glioma...) : The inhibition of PI 3-kinase activity sensitized CGNs to FasL induced caspase-8 and caspase-3 processing and caspase dependent fodrin cleavage
Kuo et al., Toxicol Appl Pharmacol 2006 : Meanwhile, immunoblotting analysis also showed that the co-administration of esculetin and Taxol could increase the expression of Bax and the cytosolic release of cytochrome C and enhance the expression of Fas and Fas ligand while the activation of caspase-8 and caspase-3 was also increased
Hu et al., Cell Mol Life Sci 2005 (Carcinoma, Hepatocellular...) : Compared with hASIP-sa, hASIP-sb accelerated Fas/FasL induced apoptosis, examined by sub-G1 accumulation, chromatin condensation, nuclear fragmentation, PARP cleavage, caspase-8 degradation and mitochondria- regulated cell death
Choi et al., Mol Carcinog 2005 (Melanoma) : Ircinin-1 also induced cytochrome c release, cleavage activations of caspase-3 and -9, and upregulation of Fas and Fas-L
Giraud et al., Apoptosis 2005 (Neuroblastoma) : Moreover, a caspase-8 inhibitor suppressed the protective effect of the concomitant BDNF and Fas ligand stimulation, suggesting that p75 ( NTR ) and Fas receptors could share common signalling pathways
Chanvorachote et al., J Biol Chem 2005 : Here we show that stimulation of the Fas receptor by its ligand (FasL) results in rapid generation of NO and concomitant decrease in cellular FLICE inhibitory protein (FLIP) expression without significant effect on Fas and Fas associated death domain (FADD) adapter protein levels
Li et al., Am J Physiol Heart Circ Physiol 2006 : ANG II-induced apoptosis was characterized by marked inhibition of Akt phosphorylation and stimulation of membrane Fas ligand (FasL) expression, caspase-8 activation , and a reduction in soluble FasL expression ... In conclusion, ANG II-induced apoptosis of hVSMC is characterized by marked inhibition of Akt phosphorylation and stimulation of an extrinsic cell death signaling pathway via upregulation of membrane FasL expression, caspase-8 activation , and a reduction in soluble FasL expression
Lee et al., EMBO J 2006 : In this study, we demonstrate a general requirement of receptor internalization for CD95 ligand mediated DISC amplification, caspase activation and apoptosis in type I cells
Brozovic et al., Microbiology 2006 : Taken together, these studies show that P. gingivalis can induce epithelial cell apoptosis through Fas-FasL up-regulation and activation of caspase-3 and caspase-8
Li et al., J Cell Physiol 2006 : A20 inhibits oxidized low-density lipoprotein induced apoptosis through negative Fas/Fas ligand dependent activation of caspase-8 and mitochondrial pathways in murine RAW264.7 macrophages ... Thus, A20 expression blocks OxLDL mediated apoptosis in murine RAW264.7 macrophages through disrupting Fas/FasL dependent activation of caspase-8 and the mitochondria pathway
Hsu et al., Biol Pharm Bull 2006 (Breast Neoplasms) : SZKJT treatment triggered the mitochondrial apoptotic pathway indicated by changing Bax/Bcl-2 ratios, cytochrome c release and caspase-9 activation, but did not act on Fas/Fas ligand pathways and the activation of caspase-8
Kanamori et al., Am J Physiol Heart Circ Physiol 2007 (Myocardial Infarction...) : By contrast, expression of Fas ligand , Bcl-2, and Fas associated death domain and activation of caspase-8 were unaffected, suggesting olmesartan exerts a negative regulatory effect on the alternate pathway downstream of Fas receptor
Xia et al., Mol Cell 2007 : The activation of caspase-7, which is independent of cytochrome c release and activation of caspase-9 and caspase-12, depends on activation of caspase-8 , which in turn requires MEK2 activity and secretion of FAS ligand
Yang et al., Leuk Res 2007 (Leukemia) : Treatment of K562 cells with IQDMA resulted in G2/M phase cell cycle arrest, presumably involving the concomitant up-regulation of p21 and apoptosis through up-regulation of FasL and sequential activation of caspase-8 and caspase-3
Fernández et al., J Neurochem 2007 (Neuroblastoma) : Reduction of endogenous LFG expression by small interfering RNA sensitized cerebellar granular neurons to FasL induced cell death and caspase-8 activation, and also increased sensitivity of cortical neurons
Purevjav et al., Cardiovasc Toxicol 2007 (Cardiomyopathies...) : These changes were associated with an increased sarcolemmal expression of Fas and FasL , as well as increased activation of caspase 3, translocation of calpain 1 to the sarcolemma and sarcomere, and increased numbers of cells undergoing apoptosis
Kim et al., Clin Cancer Res 2007 (Colonic Neoplasms) : Apicularen A caused accumulation of sub-G ( 1 ) -G ( 0 ), DNA fragmentation, Fas ligand induction, and activation of caspase-8 and caspase-3, but mitochondrial membrane potential was not changed
Gillenwater et al., Mol Cancer Ther 2007 (Carcinoma, Squamous Cell...) : SAHA also activated the extrinsic apoptosis pathway, including increased Fas and Fas ligand (FasL) expression, activation of caspase-8 , and cleavage of Bid
Yuan et al., Amino Acids 2008 (MAP Kinase Signaling System) : TIMP-3 treatment induced the expression of Fas and Fasl proteins, and the activation of caspase-8 and caspase-3
Maity et al., J Biol Chem 2008 (Stomach Diseases) : Lansoprazole also inhibits indomethacin induced Fas mediated mucosal cell death by down regulating Fas or FasL expression and inhibiting caspase-8 activation
Lee et al., Mol Nutr Food Res 2008 (Melanoma) : To confirm the geraniin-relevant signaling pathway, using immunoblot analysis we found that geraniin induced apoptosis was associated with the up-regulation of Fas ligand expression, the activation of caspase-8 , the cleavage of Bid, and the induction of cytochrome c release from mitochondria to the cytosol
Dai et al., Zhonghua Wei Chang Wai Ke Za Zhi 2008 (Stomach Neoplasms) : Matrine injection can induce apoptosis of SGC-7901 cells through the up-regulation of Fas/FasL expression and activation of caspase-3
Tan et al., Circulation 2008 : Isoproterenol and aldosterone upregulate Fas ligand expression, and Fas ligand and caspase-8 are required for isoproterenol and aldosterone to induce apoptosis
Walter et al., Hepatology 2008 : In such in vitro cultures, Fas ligand (FasL) activates caspase-3 without Bid cleavage, Bax/Bak activation or cytochrome c release, and neither Bid ablation nor Bcl-2 overexpression is protective
Stravopodis et al., Int J Oncol 2009 (Carcinoma, Transitional Cell...) : Doxorubicin induced dose dependent G2/M and/or G1/S cell cycle arrest, followed by grade- and dose dependent reduction in the amount of the cytosolic trimeric form of FasL , activation of Caspase-8 , Caspase-9, Caspase-3, cleavage of PARP, Lamin A/C, Bcl-XL/S and interestingly Hsp90, and finally cell death
Kim et al., Immunol Lett 2009 : FasL linking to Fas on DCs triggers the activation of caspase-8 , which eventually leads to mitochondria mediated apoptosis via truncation of BID
Chen et al., Mol Cell Biol 2009 : Autocrine secretion of FAS ligand and upregulated FAS expression induced by UVB irradiation contributed to activation of caspase-10 , which cleaved Hsp90 beta at D278, P293, and D294
Dai et al., J Ethnopharmacol 2009 (Stomach Neoplasms) : Matrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3
Morgan et al., J Immunol 2009 : Membrane bound Fas ligand requires RIP1 for efficient activation of caspase-8 within the death inducing signaling complex
George et al., J Neurosci Res 2010 (Neuroblastoma) : Genistein triggered the receptor mediated apoptotic pathway through upregulation of TNF-alpha, FasL , TRADD, and FADD and activation of caspase-8
Liu et al., Cancer Lett 2010 (Liver Neoplasms) : In addition, the pretreatment of BrTet or Vrp followed by Dox induced activation of caspase-3 , release of cytochrome c and AIF from mitochondria into cytosol, loss of mitochondrial transmembrane potential ( DeltaPsi ( m ) ) and elevation of Bax/Bcl-2 ratio, with no effect on activation of caspase-8 and the expression of Fas/FasL
Sodhi et al., Toxicol Mech Methods 2004 : UVB ( 100 mJ/cm ( 2 ) ) irradiation induced apoptosis in macrophages concurrent with expression of Fas, Fas ligand , Fas associated death domain (FADD), activation of caspase-8 , -3 and cleavage of poly ( ADP-ribose ) polymerase ( PARP )
Zhang et al., Mol Carcinog 2010 (Prostatic Neoplasms) : Importantly, experimentally lowering FasL expression by siRNA significantly inhibited UA-induced caspase-8 activation and at least partly attenuated the consequent apoptosis, suggesting an involvement of FasL and its regulating pathway in the cell killing effect of UA
Lokeshwar et al., Cancer Res 2010 (Neoplasm Invasiveness...) : 4-MU induced caspase-8, caspase-9, and caspase-3 activation , PARP cleavage, upregulation of Fas-L , Fas, FADD and DR4, and downregulation of bcl-2, phosphorylated bad, bcl-XL, phosphorylated Akt, phosphorylated IKB, phosphorylated ErbB2, and phosphorylated epidermal growth factor receptor
Hanaoka et al., J Immunol 2010 (Autoimmune Diseases...) : We describe a mechanism whereby NKG2D signaling in human T and NK cells initiates Fas ligand/Fas mediated caspase-3/-7 activation and resultant CD3? degradation
Farley et al., Am J Dermatopathol 2011 (Dermatitis...) : Inhibition of caspase activity dramatically augmented the FasL induced proinflammatory responses, suggesting an `` apoptosis-versus-inflammation '' antagonism in cutaneous aGvHR and other lichenoid dermatoses
Liang et al., Cancer Chemother Pharmacol 2012 (Osteosarcoma) : The induction of apoptosis appears to occur through the upregulation of Fas/FasL and Bax, downregulation of Bcl-2, and activation of caspase-3 , -8, and -9, which then trigger major apoptotic cascades
Liu et al., Int J Biochem Cell Biol 2011 (Breast Neoplasms) : Taken together, our data indicate that Akt/ERK mediated caspase-8 activation and Fas/FasL mediated caspase-8 activation mostly elucidate doxorubicin induced death in MCF-7 cells and MCF-7/Dox cells, respectively
Wang et al., Arch Med Res 2011 (Leukemia) : 2-Hydroxy-3-methylanthraquinone from Hedyotis diffusa WILLD induces apoptosis via alteration of Fas/FasL and activation of caspase-8 in human leukemic THP-1 cells
Liu et al., J Biol Chem 2012 (Colonic Neoplasms...) : Moreover, although canonical NF-?B protected mouse embryo fibroblast (MEF) cells from TNFa induced apoptosis, knocking out p65 diminished Fas expression in MEF cells, resulting in inhibition of FasL induced caspase 8 activation and apoptosis
Sareen et al., PloS one 2012 (Muscular Atrophy, Spinal) : During motor neuron development, both SMA lines showed an increase in Fas ligand mediated apoptosis and increased caspase-8 and-3 activation
Krishna et al., J Immunol 2012 (Disease Models, Animal...) : caIKKß T cells showed increased Fas ligand expression and caspase-8 activation, and blocking Fas/Fas ligand interactions enhanced cell survival
Aguirre et al., J Cell Physiol 2013 : Also, oxidized-ATP or Brilliant Blue G, two P2X(7) R blockers, reduced FasL induced caspase-9 activation and cell death
Nepal et al., Biochem Pharmacol 2012 : In the present study, we demonstrated that gAcrp significantly inhibits both ethanol induced increase in Fas ligand expression and activation of caspase-3 in human hepatoma cell lines ( HepG2 cells ), suggesting that gAcrp plays a protective role against ethanol induced apoptosis in liver cells
Keswani et al., Parasite Immunol 2013 (Malaria...) : Flow cytometric analysis reveals up-regulation of Fas-L followed by caspase-8 and caspase-3 activation and signifies possible involvement of Fas-L mediated splenocyte apoptosis
Wang et al., Eur J Immunol 2013 (Encephalomyelitis, Autoimmune, Experimental...) : In vitro, FasL ( + ) but not FasL ( - ) astrocytes induced caspase-3 expression and apoptosis of activated T cells
Hueber et al., Eur J Pharmacol 1998 (Brain Neoplasms...) : Priming with cytotoxic drugs greatly increases CD95 ligand induced caspase 3 activity, indicating that the cytotoxic drugs positively modulate the CD95 dependent signalling cascade up-stream of caspase 3 activation