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Edelstein et al., J Am Soc Nephrol 1999 (Anoxia...) : The calpain inhibitor ( 2 ) -3- ( 4-iodophenyl ) -2-mercapto-2-propenoic acid ( PD150606 ) also inhibited the hypoxia induced increase in caspase activity in proximal tubules, but did not inhibit the activity of purified caspase 1 in vitro
McCollum et al., J Neurochem 2002 : Calpain inhibitor III ( MDL-28170 ) reduced caspase activation, suggesting that caspase activation was mediated by calpain
Neumar et al., J Biol Chem 2003 (Necrosis) : Calpastatin overexpression decreased calpain activation, increased caspase-3-like activity, and accelerated the appearance of apoptotic nuclear morphology ... However, this protective effect was lost at higher staurosporine doses ( 0.5-1.0 microm ), which resulted in pronounced caspase mediated degradation of the overexpressed calpastatin ... Subsequent calpain activity, facilitated by caspase mediated degradation of calpastatin , contributes to plasma membrane disruption and secondary necrosis
Tamura et al., Int J Mol Med 2003 : Calpeptin, a calpain inhibitor , did not inhibit caspase-3 activation, Bax cleavage or apoptosis
Vaisid et al., Biochim Biophys Acta 2005 : Calpastatin ( calpain endogenous specific inhibitor, and a known caspase substrate ) is diminished at the later stages of PC12 cell differentiation, and diminution is prevented by caspase-1 inhibition
Han et al., J Pharmacol Exp Ther 2006 (Brain Ischemia...) : Because CaM binds directly to calpastatin, we asked whether a novel CaM antagonist, 3- [ 2- [ 4- ( 3-chloro-2-methylphenylmethyl ) -1-piperazinyl ] ethyl ] -5,6-dimethoxy-1- ( 4-imidazolylmethyl ) -1H-indazole dihydro-chloride 3.5 hydrate ( DY-9760e ), inhibits caspase-3 induced calpastatin degradation during ME-induced neuronal damage ... Taken together, both inhibition of caspase-3 induced calpastatin degradation and calpain induced fodrin breakdown by DY-9760e in part mediate its neuroprotective action
Dursun et al., American journal of physiology. Renal physiology 2006 (Necrosis) : Calpain inhibitor had no effect on caspase-3-like activity
Kim et al., Int J Parasitol 2007 (Entamoebiasis) : Our results suggest that calpain mediated calpastatin degradation plays a crucial role in regulation of caspase-3 activation during apoptosis of Jurkat T cells by E. histolytica
Vaisid et al., Int J Biochem Cell Biol 2009 (Alzheimer Disease...) : We previously found that Abeta promoted degradation of calpastatin ( the specific endogenous calpain inhibitor ) ; calpastatin degradation was prevented by inhibitors of either calpain or caspase-8
Nelson et al., Crit Care Med 2012 (Muscular Atrophy) : Lastly, caspase-3 inhibition prevented the mechanical ventilation induced degradation of the endogenous calpain inhibitor, calpastatin
Yang et al., In Vitro Cell Dev Biol Anim 2012 : Here, we conclude that CAPN1, calpastatin , caspase 3, caspase 7, caspase 8, and CARD9 have important roles for satellite cell myogenesis ; and that caspase 7, 12, HSP70, and HSP90 are involved in the process of apoptotic cell death under hypoxia conditions and we speculate that these proteins may be involved in early postmortem proteolysis and meat tenderization
Suwanjang et al., Neurosci Lett 2012 (Neuroblastoma) : Calpastatin reduces calpain and caspase activation in methamphetamine induced toxicity in human neuroblastoma SH-SY5Y cultured cells ... The purpose of the present study was to investigate the functional role of calpastatin , a specific endogenous calpain inhibitor protein, on caspase and calpain activation in METH induced degeneration in neuroblastoma SH-SY5Y cell cultures