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JAK2 — TCF25

Text-mined interactions from Literome

Madden et al., J Immunol 2002 : Binding of IL-4 by either the type 1 or 2 IL-4R, or of IL-13 by the type 2 IL-4R, initiates Jak dependent tyrosine phosphorylation of the IL-4Ralpha-chain and the transcription factor , STAT6
Tanimoto et al., J Biol Chem 2008 (Inflammation) : Furthermore, analysis of the GM-CSF promoter element revealed that the STAT5 ( signal transducer and activator of transcription-5 ) transcription factor binding site, located between -152 and -144 upstream of the transcription start site, as well as Janus kinase-2 mediated Stat5 activation were necessary for the GM-CSF induced transcriptional up-regulation of the MCP-1 gene
Wei et al., Acta Pharmacol Sin 2013 : Furthermore, the treatment selectively prevented the activation of MAPKs, AKT and transcription factor AP-1 component c-Jun, but not the recruitment of TRAF6 or the activation of JAK2/STAT3