Gene interactions and pathways from curated databases and text-mining

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POLDIP2 — TNFSF11

Text-mined interactions from Literome

Kim et al., Mol Pharmacol 2007 (Calcium Signaling) : Subsequent characterization of the DMS mediated suppression of osteoclastogenesis revealed that DMS did not affect RANKL induced activation of JNK, p38 , NF-kappaB, and Ca2+ oscillation
Murakami et al., Biofactors 2007 : RANKL-up regulated extracellular signal regulated kinase ( ERK ) 1/2 and p38 mitogen activated protein kinase ( MAPK ) activities were attenuated by PEITC, whereas c-Jun N-terminal kinase (JNK1/2) activation was increased
Tsai et al., Eur J Pharmacol 2008 : Our data suggest that paeonol inhibits osteoclastogenesis from bone marrow stromal cells and macrophage cells via attenuated of RANKL induced ERK, p38 and NF-kappaB activation, which in turn protect bone loss from ovariectomy
Hasegawa et al., Biol Pharm Bull 2010 (Bone Resorption) : In experiments to elucidate its mechanism of action, honokiol was found to suppress RANKL induced phosphorylation of p38 mitogen activated protein kinase ( MAPK ), extracellular signal regulated kinase ( ERK ), and c-Jun N-terminal kinase (JNK)