UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to MAPK14

MAPK14 — TNFSF10

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: MAPK14 → TNFSF10 (increases, TNFSF10 Activity) Varfolomeev et al., J Biol Chem 2005 *
Evidence: Apo2L/TRAIL stimulation of JNK and p38 further depended on RIP1 and TRAF2, whereas IKK activation required NEMO.

Text-mined interactions from Literome

Secchiero et al., Blood 2004 (MAP Kinase Signaling System) : Among the intracellular pathways investigated, TRAIL significantly stimulated the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the p38/mitogen activated protein kinase ( MAPK ) or the c-Jun NH2-terminal kinase (JNK) pathway
Sun et al., Oncol Rep 2011 : Taken together, we show herein that the upstream molecule of the TRAIL induced MAPK activation is MEKK, as opposed to ASK1, via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner