◀ Back to MAPK14

MAPK14 — MAPKAPK2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPKAPK2 → MAPK14 (directlyIncreases, MAPKAPK2 Activity) Ben-Levy et al., EMBO J 1995*
  Evidence: PhosphoElm data from PMID 15212693
• BioCarta p38 mapk signaling pathway: p38 (MAPK14) → MAPKAPK2 (modification, activates)
• KEGG VEGF signaling pathway: MAPK11/MAPK12/MAPK13/MAPK14 → MAPKAPK2/MAPKAPK3 (protein-protein, activation)
• KEGG Neurotrophin signaling pathway: MAPK11/MAPK12/MAPK13/MAPK14 → MAPKAPK2 (protein-protein, activation)
• KEGG MAPK signaling pathway: MAPK11/MAPK12/MAPK13/MAPK14 → MAPKAPK2/MAPKAPK3 (protein-protein, phosphorylation)
• NCI Pathway Database p38 signaling mediated by MAPKAP kinases: p38alpha-beta/MAPKAPK2 complex (MAPK14_MAPK11-MAPKAPK2) → CDC25B (CDC25B) (modification, activates) Bulavin et al., Nature 2001, Manke et al., Mol Cell 2005
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL2-mediated signaling events: p38alpha-beta-active (MAPK14/MAPK11) → MAPKAPK2 (MAPKAPK2) (modification, activates) Hunt et al., J Biol Chem 1999, Crawley et al., J Biol Chem 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database p38 signaling mediated by MAPKAP kinases: p38alpha-beta/MAPKAPK2 complex (MAPK14_MAPK11-MAPKAPK2) → 5-LO (MAPK14) (modification, activates) Werz et al., Proc Natl Acad Sci U S A 2000*, Werz et al., J Biol Chem 2002*
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling mediated by p38-alpha and p38-beta: p38alpha-beta-active (MAPK14/MAPK11) → p38alpha-beta/MAPKAPK2 complex (MAPK14_MAPK11-MAPKAPK2) (modification, collaborate)
  Gum et al., Biochem Biophys Res Commun 1999*, Cuenda et al., FEBS Lett 1995*, Rouse et al., Cell 1994*, Freshney et al., Cell 1994*
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Signaling mediated by p38-alpha and p38-beta: p38alpha-beta-active (MAPK14/MAPK11) → MAPKAPK2 (MAPKAPK2) (modification, collaborate) Gum et al., Biochem Biophys Res Commun 1999*, Cuenda et al., FEBS Lett 1995*, Rouse et al., Cell 1994*, Freshney et al., Cell 1994*
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Signaling mediated by p38-alpha and p38-beta: p38alpha-beta/MAPKAPK2 complex (MAPK14_MAPK11-MAPKAPK2) → MAPKAPK2 (MAPKAPK2) (modification, collaborate) Gum et al., Biochem Biophys Res Commun 1999*, Cuenda et al., FEBS Lett 1995*, Rouse et al., Cell 1994*, Freshney et al., Cell 1994*
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database p38 signaling mediated by MAPKAP kinases: TCF3 (TCF3) → p38alpha-beta/MAPKAPK2 complex (MAPK14_MAPK11-MAPKAPK2) (modification, collaborate)
  Neufeld et al., J Biol Chem 2000
  Evidence: reporter gene, physical interaction
• NCI Pathway Database p38 signaling mediated by MAPKAP kinases: TCF3 (TCF3) → p38alpha-beta/MAPKAPK2/TCF3 complex (MAPK14_MAPK11-MAPKAPK2-TCF3) (modification, collaborate)
  Neufeld et al., J Biol Chem 2000
  Evidence: reporter gene, physical interaction
• NCI Pathway Database p38 signaling mediated by MAPKAP kinases: p38alpha-beta/MAPKAPK2 complex (MAPK14_MAPK11-MAPKAPK2) → p38alpha-beta/MAPKAPK2/TCF3 complex (MAPK14_MAPK11-MAPKAPK2-TCF3) (modification, collaborate)
  Neufeld et al., J Biol Chem 2000
  Evidence: reporter gene, physical interaction
• Reactome Reaction: MAPKAPK2 → MAPK14 (reaction) Lukas et al., Biochemistry 2004*, ter Haar et al., J Biol Chem 2007, White et al., Proc Natl Acad Sci U S A 2007*, Sithanandam et al., Mol Cell Biol 1996*, McLaughlin et al., J Biol Chem 1996*, Clifton et al., FEBS Lett 1996, Ben-Levy et al., EMBO J 1995*
• Reactome Reaction: MAPKAPK2 → MAPK14 (direct_complex) Meng et al., J Biol Chem 2002*, Lukas et al., Biochemistry 2004*, ter Haar et al., J Biol Chem 2007, White et al., Proc Natl Acad Sci U S A 2007*, Raingeaud et al., J Biol Chem 1995, Raingeaud et al., Mol Cell Biol 1996, Sithanandam et al., Mol Cell Biol 1996*, McLaughlin et al., J Biol Chem 1996*, Clifton et al., FEBS Lett 1996, Ben-Levy et al., EMBO J 1995*, Ben-Levy et al., Curr Biol 1998*
• WikiPathways Structural Pathway of Interleukin 1 (IL-1): MAPK14 → MAPKAPK2 (activation)
• WikiPathways p38 MAPK Signaling Pathway: MAPK14 → MAPKAPK2 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAPKAPK2 — MAPK14 (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Biogrid Interaction: MAPKAPK2 — MAPK14 (physical association, affinity chromatography technology) Rane et al., J Biol Chem 2001*
• IRef Biogrid Interaction: MAPKAPK2 — MAPK14 (direct interaction, protein complementation assay) Srivastav et al., Biochem J 2011
• IRef Biogrid Interaction: MAPKAPK2 — MAPK14 (physical association, affinity chromatography technology) Janknecht et al., J Biol Chem 2001*
• IRef Biogrid Interaction: MAPKAPK2 — MAPK14 (physical association, affinity chromatography technology) Varjosalo et al., Nat Methods 2013
• IRef Hprd Interaction: MAPK14 — MAPKAPK2 (two hybrid) Engel et al., J Biol Chem 1995*, Ben-Levy et al., EMBO J 1995*, Ben-Levy et al., Curr Biol 1998*
• IRef Hprd Interaction: MAPK14 — MAPKAPK2 (in vitro) Engel et al., J Biol Chem 1995*, Ben-Levy et al., EMBO J 1995*, Ben-Levy et al., Curr Biol 1998*
• IRef Hprd Interaction: MAPK14 — MAPKAPK2 (in vivo) Engel et al., J Biol Chem 1995*, Ben-Levy et al., EMBO J 1995*, Ben-Levy et al., Curr Biol 1998*
• IRef Innatedb Interaction: MAPKAPK2 — MAPK14 (unknown, -) ter Haar et al., J Biol Chem 2007
• IRef Innatedb Interaction: MAPKAPK2 — MAPK14 (unknown, -) Gum et al., Biochem Biophys Res Commun 1999*
• IRef Intact Interaction: Complex of 11 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of 19 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of MAPK14-MKNK1-MAPKAPK2-OBSL1-MAPKAPK3-CUL7-CCDC8 (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: MAPKAPK2 — MAPK14 (direct interaction, x-ray crystallography) ter Haar et al., J Biol Chem 2007
• IRef Intact Interaction: MAPKAPK2 — MAPK14 (physical association, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Ophid Interaction: MAPKAPK2 — MAPK14 (aggregation, confirmational text mining) Ben-Levy et al., Curr Biol 1998*
• IRef Ophid Interaction: MAPKAPK2 — MAPK14 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Bartlett et al., J Physiol 1999 : Induction of MAPKAP kinase-2 activity was prevented by the p38 MAPK inhibitor SB 203580 ( 10 microm, 5-30 min )
Martel-Pelletier et al., Arthritis Rheum 1999 (Osteoarthritis) : Mitogen activated protein kinase and nuclear factor kappaB together regulate interleukin-17 induced nitric oxide production in human osteoarthritic chondrocytes : possible role of transactivating factor mitogen activated protein kinase activated proten kinase ( MAPKAPK )
Aicher et al., J Immunol 1999 : The p38 MAPK-specific inhibitor, SB203580, blocked CD40 induced MAPKAPK-2 activation, but did not affect activation of c-Jun N-terminal kinase
Ishizuka et al., J Immunol 2001 : Both p38 MAPK and MAPK activated protein kinase (MAPKAPK)2 were activated following Fc ( epsilon ) RI aggregation, and activation of MAPKAPK2 was almost completely inhibited by 10 microM SB203580
Matsuda et al., Cancer Res 2002 (MAP Kinase Signaling System...) : In ASPC-1, PANC-1, and T3M4 cells, PD98059 and U0126 inhibited MAPK kinase activation but not EGF stimulated mitogenesis, whereas SB203580 inhibited EGF stimulated mitogenesis, p38 MAPK activation, and MAPK activated protein kinase 2 activation, without attenuating the mitogenic effect of insulin-like growth factor 1
Fegley et al., J Surg Res 2003 : S-1-P stimulated activation of p38 ( MAPK ) that peaked at 10 min, as well as activation of MAPKAP kinase-2
Coxon et al., Cell Signal 2003 (MAP Kinase Signaling System) : MAPK activated protein kinase-2 (MK2) is activated by p38 MAPK in human neutrophils
Hu et al., J Biol Chem 2006 (MAP Kinase Signaling System) : MAPKAPK-2 , Akt2, and ezrin phosphorylation were all attenuated by p38 MAPK inhibition but were unaffected by dominant negative ezrin expression ... siRNA mediated MAPKAPK-2 knockdown inhibited phosphorylation of Akt2 and ezrin but not p38 MAPK
Su et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : TNF stimulation induced p38 MAPK dependent phosphorylation of MK2 and HSP27
Duraisamy et al., Expert Opin Ther Targets 2008 (Inflammation) : Mitogen activated protein kinase ( MAPK) activated protein kinase 2 (MK2 ) is activated upon stress by p38 MAPK
Dingar et al., Cell Signal 2010 (Cardiomegaly...) : Whereas MK2 and MK3 are activated by p38 MAPK , MK5 has also been shown to be activated by ERK3 and ERK4
Shiryaev et al., Journal of molecular signaling 2011 : Stimulation of the p38MAPK , but not the PKA pathway, caused activation of MK2
Anur et al., Blood 2012 (Disease Models, Animal...) : Low doses ( 50nM ) of both agents inhibited p38 MAPK dependent activation of MAPKAPK2 (MK2) and suppressed MK2 dependent TNFa production without substantially influencing TNFa gene transcription
Xu et al., PloS one 2012 (Breast Neoplasms) : PIC induced activation of p38 MAPK and MK2 was attenuated by the PKR inhibitor and the PKR siRNA, but a selective p38 MAPK inhibitor ( SB203580 ) or other MAPK inhibitors did not affect PKR activity, indicating that PKR is upstream of p38 MAPK/MK2
Huot et al., Eur J Biochem 1995 : In all cases, the induced kinase activity was entirely associated with two polypeptides of 45 kDa and 54 kDa, identified as mitogen-activated-protein kinase activated protein ( MAPKAP) kinase-2 based on its reactivation in vitro by 42/44-kDa MAP kinases, its antigenic properties and its substrate specificity
Groblewski et al., Gastroenterology 1997 : Cholecystokinin stimulated mitogen activated protein kinase activated protein ( MAPKAP) kinase 2 activity was measured after immunoprecipitation of the kinase
Komatsu et al., Arch Biochem Biophys 1997 : The protein kinase activity of GST-MAPKAPK-4 was activated by MAPK and this enabled the kinase to phosphorylate both glycogen synthase N-terminal peptide and the regulatory light chain of myosin II in vitro
Hodge et al., J Biol Chem 1998 : GH slightly increased p38 mediated mitogen activated protein kinase activated protein ( MAPKAP) kinase-2 activity, but the p38 inhibitor SB203580 did not attenuate GH-promoted Elk-1 phosphorylation
Marshall et al., J Immunol 1998 : IL-4 induced a late ( > 4-h ) increase in p38 MAPK activity and corresponding activation of its substrate MAPKAPK-2