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CDH1 — UBE2E1
Text-mined interactions from Literome
Kramer et al., Mol Biol Cell 2000
:
The ordered
activation of the ubiquitin protein ligase
anaphase promoting complex (APC) or cyclosome by CDC20 in metaphase and by
CDH1 in telophase is essential for anaphase and for exit from mitosis, respectively
Pfleger et al., Genes Dev 2001
:
Despite evidence showing that Cdc20 and
Cdh1 bind and
activate the
anaphase promoting complex (APC) in a substrate-specific manner, there is no evidence that the activating protein and substrate interact directly ; hence, no clear model exists for the mechanism of APC activation or recruitment of substrates
Wan et al., Proc Natl Acad Sci U S A 2001
:
CDC20/CDH1 activates the
anaphase promoting complex (APC) and targets various substrates for degradation, thereby allowing the ordered progression through mitosis and G ( 1 )
Zhou et al., Biochem Biophys Res Commun 2002
:
The
anaphase promoting complex (APC) is a major component of this degradation machinery and its activation is
regulated by CDC20 and
CDH1
Zhou et al., J Biol Chem 2003
:
The
anaphase promoting complex activated by CDC20 and
CDH1 is a major ubiquitination system that controls the destruction of cell cycle regulators
Kraft et al., Mol Cell 2005
:
Activation of the
anaphase promoting complex/cyclosome ( APC/C ) by Cdc20 and
Cdh1 leads to ubiquitin dependent degradation of securin and cyclin B and thereby promotes the initiation of anaphase and exit from mitosis
Reis et al., Nat Cell Biol 2006
:
Cdh1 is an
activator of the
anaphase promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle
Martinez et al., Mol Cell Biol 2006
:
Acm1 is a negative regulator of the
CDH1 dependent
anaphase promoting complex/cyclosome in budding yeast
Medendorp et al., PloS one 2009
:
Although MAD2B is thought to
inhibit the
anaphase promoting complex (APC) by binding to CDC20 and/or
CDH1 ( FZR1 ), its exact role in cell cycle control still remains to be established
Wäsch et al., Oncogene 2010
(Genomic Instability...) :
The
anaphase promoting complex or cyclosome ( APC/C )
activated by
Cdh1 coordinately eliminates positive cell-cycle regulators as well as inhibitors of differentiation, thereby coupling cell-cycle exit and differentiation
Naoe et al., Mol Cell Biol 2010
:
Cdh1 is an
activator of the
anaphase promoting complex/cyclosome and contributes to mitotic exit and G ( 1 ) maintenance by targeting cell cycle proteins for degradation
Medendorp et al., PloS one 2010
:
Although the mitotic arrest deficient protein MAD2B ( MAD2L2 ) is thought to
inhibit the
anaphase promoting complex (APC) by binding to CDC20 and/or
CDH1 ( FZR1 ), its exact role in cell cycle control still remains to be established
Naoe et al., Biochem Biophys Res Commun 2013
:
Here, we report that
Cdh1 , a
regulator of the
anaphase promoting complex/cyclosome ( APC/C ), negatively regulates mitotic entry upon the mitotic/endocycle transition
Fang et al., Genes Dev 1998
:
Activation of the
anaphase promoting complex (APC) by binding of CDC20 and
CDH1 is required for exit from mitosis, and APC has been implicated as a target for the checkpoint intervention