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CDH1 — TP53
Text-mined interactions from Literome
Lam et al., Ann Acad Med Singapore 1999
(Helicobacter Infections...) :
p53 mutation, cyclin overexpression ( especially in intestinal type ), microsatellite instability, down
regulation of
E-cadherin ( especially in diffuse type ), and telomerase reactivation are some prominent examples
Fan et al., American journal of physiology. Renal physiology 2005
(Prenatal Exposure Delayed Effects) :
In transient transfection assays,
p53 repressed human
E-cadherin promoter-driven reporter activity, whereas a mutant p53, which can not bind DNA, did not
Roger et al., J Cell Sci 2010
(Colonic Neoplasms...) :
Gain of oncogenic function of
p53 mutants
regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells ... In addition, knockdown of Slug and Zeb-1 expression diminished
p53 mediated
E-cadherin repression ... Knocking down endogenous mutant
p53 in MDA-MB-231 and SW620 cancer cell lines lacking E-cadherin protein
restored the expression of
E-cadherin
Cheng et al., Oncogene 2011
(Carcinoma...) :
Inhibition of
p53 represses
E-cadherin expression by increasing DNA methyltransferase-1 and promoter methylation in serous borderline ovarian tumor cells ... The increase in DNMT1 was associated with the inhibition of
p53 induced downregulation of
E-cadherin and cell invasion