Sakai et al., J Biol Chem 1999
(MAP Kinase Signaling System) :
L- and N-types of voltage dependent Ca ( 2+ ) channel blockers, diltiazem and omega-conotoxin, inhibited MSH induced neurite outgrowth and MAPK phosphorylation in a Ca ( 2+ ) -dependent manner
Eriksson et al., J Ethnopharmacol 2008
:
We also demonstrate that Panax ginseng, endothelin-3 (ET-3) and alpha-melanocyte stimulating hormone ( MSH ) stimulate an activation of mitogen activated protein kinase ( MAPK ) ... Pre-incubation with M-EGF decreased the MAPK activity induced by ET-3 and MSH , but again only marginally affected the response of Panax ginseng
Doyle et al., J Pharmacol Exp Ther 2012
(Inflammation) :
In contrast, the R163Q variant displayed a selective loss of a-MSH induced MAPK activation ; whereas responsiveness to the small-molecule agonist BMS-470539 was preserved