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CALM3 — IL10
Text-mined interactions from Literome
Ito et al., J Biol Chem 1991
:
These results indicate that
calmodulin is
required for the
interleukin 1-enhanced synthesis of TIMP but it is a suppressor for the synthesis of proMMPs-1 and -3
Gee et al., J Immunol 2007
:
The experiments designed to further understand the molecules involved in the calcium signaling suggested that
calmodulin and calmodulin dependent protein kinase-II ( CaMK-II ) -activated p38 MAPK
played a role in extracellular Tat induced
IL-10 expression in primary human monocytes
Sugiyama et al., Clin Exp Immunol 2007
:
Because dendritic cells (DCs) orchestrate immune responses, we examined the in vitro
effects of
clarithromycin (CAM) , azithromycin ( AZM ) and midecamycin ( MDM ) on the expression of co-stimulatory molecules and production of cytokines
[interleukin (IL)-10, IL-6, interferon (IFN)-gamma, IL-12p40, tumour necrosis factor (TNF)-alpha ] of murine bone marrow derived DCs by lipopolysaccharide (LPS) stimulation
Yokota et al., Mediators Inflamm 2012
(Respiratory Syncytial Virus Infections) :
Clarithromycin (CAM) , which is an antimicrobial agent and is also known as an immunomodulator, significantly
suppressed RSV induced production of interleukin-6,
interleukin-8 , and regulated on activation, normal T-cell expressed and secreted ( RANTES )
Cai et al., Immunobiology 2013
(Cryptogenic Organizing Pneumonia) :
CAM also
inhibited the LPS stimulated TNF-a, IL-1ß, IL-6 and
IL-10 production
Ojima et al., Biochim Biophys Acta 1989
:
Calmodulin regulates the
interleukin 1-induced procollagenase production in human uterine cervical fibroblasts
Morikawa et al., Antimicrob Agents Chemother 1996
:
Namely, FOM enhanced both IL-6 and IL-10 synthesis,
CAM enhanced only
IL-10 synthesis, but dexamethasone deeply suppressed the synthesis of both cytokines