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NPEPPS — PRKACB
Text-mined interactions from Literome
Andrews et al., Cancer Res 1992
(Prostatic Neoplasms) :
In this study, we examine the
effects of
protein kinase A (PKA) and protein kinase C ( PKC ) on the androgen regulation of
PSA in a human adenocarcinoma cell line, LNCaP
Kim et al., J Mol Endocrinol 2005
:
Interestingly, when either p300 or CBP was overexpressed,
PKA activation was
sufficient to stimulate
PSA promoter-driven transcription in the absence of androgen, which was not inhibited by bicalutamide
Shigemura et al., Prostate 2009
(MAP Kinase Signaling System...) :
We observed ERK kinase inhibitor, U0126, but not phosphatidylinositol 3-kinase (PI-3K), LY294002, or
protein kinase A (PKA) inhibitor, H-89,
inhibited stromal CM or androgen induced
PSA promoter luciferase activities, and anchorage independent growth of LNCaP cells