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APOB — MAPK12

Text-mined interactions from Literome

Metzler et al., Arterioscler Thromb Vasc Biol 1999 : LDL stimulates mitogen activated protein kinase phosphatase-1 expression, independent of LDL receptors, in vascular smooth muscle cells
Hackeng et al., Thromb Haemost 1999 : LDL induced a rapid and dose dependent activation of p38MAPK ... Integrins alphaIIbbeta3 and alpha2beta1, as well as the FcgammaRII-receptor, CD36 ( platelet glycoprotein IV ), CD68 ( gp110 ) and Low Density Lipoprotein-receptor related protein ( LRP ) were not implicated in LDL induced p38MAPK-activation ... Inhibition of LDL binding by modification of apo B100 lysines reduced p38MAPK-activation by 80 %
Yang et al., Cell Signal 2000 : In cells pretreated with PMA for 24 h and with either the PKC inhibitor staurosporine or the tyrosine kinase inhibitor genistein for 1h, substantially reduced the [ 3H ] thymidine incorporation and p42/p44 MAPK phosphorylation in response to OX-LDL ... Furthermore, we also showed that overexpression of dominant negative mutants of Ras ( RasN17 ) and Raf ( Raf-301 ) completely suppressed MEK1/2 and p42/p44 MAPK activation induced by OX-LDL and PDGF-BB, indicating that Ras and Raf may be required for activation of these kinases ... Therefore, we investigated the effect of OX-LDL on cell proliferation associated with a specific pattern of mitogen activated protein kinase ( MAPK ) by [ 3H ] thymidine incorporation and p42/p44 MAPK phosphorylation in canine cultured VSMCs. OX-LDL induced [ 3H ] thymidine incorporation and p42/p44 MAPK phosphorylation in a time- and concentration dependent manner in VSMCs. Pretreatment of these cells with pertussis toxin ( PTX ) for 24 hours attenuated the OX-LDL induced [ 3H ] thymidine incorporation and p42/p44 MAPK phosphorylation, indicating that these responses were mediated through a receptor coupled to a PTX-sensitive G protein
Li et al., Circulation 2000 : Activation of mitogen activated protein kinase ( MAPK ) may play a critical role in signal transduction in ox-LDL mediated alteration in MCP-1 expression, since antisense LOX-1, but not the sense LOX-1, completely inhibited the ox-LDL induced MAPK activation
Yang et al., Br J Pharmacol 2001 (MAP Kinase Signaling System) : OX-LDL induced time- and concentration dependent phosphorylation of p42/p44 MAPK ... 4. Pretreatment with PMA for 24 h, preincubation with a PKC inhibitor staurosporine or the tyrosine kinase inhibitors, genistein and herbimycin A for 1 h, substantially reduced [ ( 3 ) H ] -thymidine incorporation and p42/p44 MAPK phosphorylation induced by OX-LDL ... 5. Removal of Ca ( 2+ ) by BAPTA/AM or depletion of the internal Ca ( 2+ ) pool by thapsigargin significantly inhibited OX-LDL induced [ ( 3 ) H ] -thymidine incorporation and p42/p44 MAPK phosphorylation ... 6. OX-LDL induced [ ( 3 ) H ] -thymidine incorporation and p42/p44 MAPK phosphorylation was inhibited by PD98059 ( an inhibitor of MEK1/2 ) and SB203580 ( an inhibitor of p38 MAPK ) in a concentration dependent manner ... 7. Overexpression of dominant negative mutants of Ras ( H-Ras-15A ) and Raf ( Raf-N4 ) significantly suppressed MEK1/2 and p42/p44 MAPK activation induced by OX-LDL and PDGF-BB, indicating that Ras and Raf may be required for activation of these kinases
Relou et al., Thromb Haemost 2002 (MAP Kinase Signaling System) : Antibody 4G3 disturbs apoB100 binding to the classical apoB/E receptor and inhibits LDL induced p38MAPK activation, whereas an antibody against a distal domain on apoB 100 has no effect
Li et al., Cardiovasc Res 2003 : In this process, ox-LDL induced activation of mitogen activated protein kinase ( MAPK p42/44 ) played an important role, since pretreatment of HCAECs with the MAPK p42/44 inhibitor ( PD98059, 10 microM ) inhibited MAPK activation and subsequently attenuated the expression of ACE ( P < 0.01 vs. ox-LDL alone ) ... Simvastatin markedly attenuated ox-LDL induced MAPK activation, and concurrently reduced ACE expression ( P < 0.01 vs. ox-LDL alone )
Relou et al., J Biol Chem 2003 : Inhibition of the Ser/Thr phosphatases PP1/PP2A ( okadaic acid ) makes the transient p38MAPK activation by LDL and the B-site peptide persistent
Ouyang et al., Di Yi Jun Yi Da Xue Xue Bao 2004 : LDL significantly enhanced the p44/42 MAPK activity, an effect obviously inhibited by green tea polyphenols ( at 100 microg/ml )
Korporaal et al., J Biol Chem 2004 : Indeed, LDL was unable to induce p38MAPK activation in platelets of apoER2-deficient mice ... Furthermore, LDL bound efficiently to soluble apoER2 ', and the transient LDL induced activation of p38MAPK was mimicked by an anti-apoER2 antibody
Mehta et al., Cardiovasc Res 2004 : Ox-LDL also enhanced the activity of p38MAPK in HCAECs, and aspirin blocked this effect of ox-LDL ( P < 0.01 )
Allister et al., Diabetes 2005 : We conclude that MAPK ( erk ) signaling in hepatocytes is critical for inhibition of apoB100 secretion by naringenin and insulin
Hao et al., Zhonghua Yi Xue Za Zhi 2006 : The p-p38MAPK protein expression was up-regulated by ox-LDL dose-dependently ( P < 0.05 )
Kosone et al., Am J Physiol Gastrointest Liver Physiol 2007 (Fatty Liver) : However, this induction of MTP and ApoB by HGF was clearly inhibited by PD98059 ( MAPK inhibitor )
Bustamante et al., Cell Mol Biol Incl Cyto Enzymol 2007 : Furthermore, oxLDL and H2O2 but not native LDL strongly enhanced phosphorylation of JNK, p38MAPK and p42/44MAPK
Taketa et al., J Biol Chem 2008 (Atherosclerosis...) : Ox-LDL induced phosphorylation of ERK1/2 and p38 MAPK , and ERK1/2 specific inhibition abrogated Ox-LDL induced COX-2 expression and PPARalpha and PPARgamma activation, whereas p38 MAPK-specific inhibition had no effect
Bulat et al., J Lipid Res 2009 (MAP Kinase Signaling System) : However, specific PI3K inhibitors or expression of a dominant negative form of Ras failed to blunt LDL induced p38 MAPK activation
Béaslas et al., PloS one 2009 : These early events included the trafficking of apolipoprotein B , a structural component of TRL, from apical towards secretory domains, and the rapid, dose dependent activation of ERK and p38MAPK
Li et al., Chin J Integr Med 2012 (Atherosclerosis...) : Andrographolide could inhibit the activation of ERK1/2, p38MAPK and NK-?B induced by ox-LDL in macrophage foam cells, which might be one of its mechanisms in preventing atherosclerosis
Mei et al., J Biol Chem 2012 : First, elevated intracellular cholesterol level induced by the exposure to LDL activated p38 MAPK and activation of p38 MAPK with anisomycin increased the ratio of cholesterol esters over free cholesterol, whereas inhibition of p38 MAPK with SB203580 or siRNA reduced the LDL loading induced intracellular accumulation of free cholesterol and cholesterol esters in macrophages
Khaidakov et al., PloS one 2012 : Ox-LDL also triggered phosphorylation of I?Ba coupled with nuclear translocation of NF-?B and stimulated p44/42 MAPK , PI3K and Akt while intracellular PTEN ( PI3K/Akt pathway inhibitor and target of miR-21 ) declined
Wang et al., Cardiovasc Drugs Ther 2013 (Atherosclerosis...) : Furthermore, TMP suppressed ox-LDL induced activations of p-ERK, p-p38, and p-JNK MAPK
Balagopalakrishna et al., Mol Cell Biochem 1997 : We have investigated the effects of modifying LDL by Cu++ and various hemoglobin preparations on aortic smooth muscle cell proliferation and on the activation of mitogen activated protein kinase ... We conclude that modification of LDL under situations that are closer to those found in vivo ( i.e. hypoxic conditions ), may involve the activation of MAPK as a common biochemical mechanism of action