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BCR — TERF2

Text-mined interactions from Literome

Gold et al., Immunol Rev 2000 : In this review, we discuss the role of phosphatidylinositol 3-kinase (PI3K) and Rap 1 in B-cell receptor (BCR) signaling ... We showed that the BCR activates Rap1 via phospholipase C-dependent production of diacylglycerol
McLeod et al., Int Rev Immunol 2001 : In this review, we summarize our recent work showing that the B cell antigen receptor (BCR) , as well as chemokine receptors, activate Rap1 via a pathway that involves phospholipase C-dependent production of diacylglycerol ( DAG ) ... The possible identities of the DAG regulated guanine nucleotide exchange factors ( GEFs ) and GTPase activating proteins ( GAPs ) that regulate the activation of Rap1 by the BCR and chemokine receptors will be discussed
Mizuchi et al., Biochem Biophys Res Commun 2005 : BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells ... Here we demonstrate that the inducible expression of BCR/ABL in a murine hematopoietic cell line, TonB210, leads to the activation of the Ras family small GTPase Rap1 , which is inhibited by the ABL kinase inhibitor imatinib
Machtaler et al., J Cell Sci 2011 : Expression of wild-type Cx43-GFP, but not Cx43dT-GFP, was sufficient to restore sustained, BCR mediated Rap1 activation and cell spreading
McLeod et al., J Biol Chem 1998 : In this report, we show that BCR engagement activates Rap1 and that this is dependent on production of diacylglycerol ( DAG ) by phospholipase C-gamma ... Activation of Rap1 by the BCR was greatly reduced in phospholipase C-gamma-deficient B cells, whereas both a synthetic DAG and phorbol dibutyrate could activate Rap1 in B cells ... However, the DAG dependent pathway by which the BCR activates Rap1 apparently does not involve Crk signaling complexes since phorbol dibutyrate could activate Rap1 without inducing the formation of these complexes ... Thus, the BCR activates Rap1 via a novel DAG dependent pathway