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PRKACB — RYR1

Text-mined interactions from Literome

Li et al., Circ Res 2002 (Calcium Signaling) : However, clear cellular data on PKA dependent modulation of cardiac RyRs is limited because of difficulty in distinguishing between PKA effects on RyR , phospholamban (PLB), and Ca2+ current
Ruehr et al., J Biol Chem 2003 : Therefore, localization of PKA by mAKAP at RyR1 increases both PKA dependent RyR phosphorylation as well as efflux of Ca2+ through the RyR
Lehnart et al., Curr Top Med Chem 2003 (Ion Channel Gating) : In addition, the FKBP-RyR interaction is regulated by PKA phosphorylation
Morimoto et al., Biochem Biophys Res Commun 2009 : The Ca ( 2+ ) leak in isoproterenol treated preparations was significantly increased when the PKA dependent phosphorylation of RyR was increased without the involvement of CaMKII dependent phosphorylation ... Both the increase in Ca ( 2+ ) leak and the phosphorylation of RyR were blocked by a PKA inhibitor ... Our results show that beta-adrenergic stimulation increases Ca ( 2+ ) leak from SR through PKA dependent phosphorylation of RyR
Ullrich et al., J Mol Cell Cardiol 2012 : During physical exercise and stress, the sympathetic system stimulates cardiac contractility via ß-adrenergic receptor activation, resulting in protein kinase A (PKA) mediated phosphorylation of the cardiac ryanodine receptor , RyR2, at Ser2808