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PDE4B — PRKACB

Pathways - manually collected, often from reviews:

• Reactome Reaction: PDE4B → PRKACB (reaction) Sette et al., J Biol Chem 1996*, Ekholm et al., Biochim Biophys Acta 1997*

Text-mined interactions from Literome

Millen et al., Eur J Cell Biol 2006 (Anoxia...) : Despite the hypoxia induced increases in the expression of PDE4A10/11, PDE4B2 and PDE4D5 and activation of certain of these long PDE4 isoforms through PKA phosphorylation, we suggest that the failure to see any overall increase in PDE4 activity is due to ERK mediated phosphorylation and inhibition of particular PDE4 long isoforms
Gobejishvili et al., J Pharmacol Exp Ther 2011 : The SAM mediated decrease in LPS-inducible Pde4b2 up-regulation resulted in an increase in cellular cAMP levels and activation of cAMP dependent protein kinase A (PKA) , which plays an inhibitory role in LPS induced TNF production