UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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GLI1 — PRKACB

Pathways - manually collected, often from reviews:

KEGG Hedgehog signaling pathway: PRKACA/PRKACB/PRKACG/PRKX → GLI1/GLI2/GLI3 (protein-protein, inhibition)
Reactome Reaction: GLI1 → PRKACB (reaction) Huntzicker et al., Genes Dev 2006, Tempé et al., Mol Cell Biol 2006, Pan et al., J Biol Chem 2007, Pan et al., Dev Biol 2009

Text-mined interactions from Literome

Kaesler et al., Biol Chem 2000 : It was found that PKA inhibits GLI1 transcriptional activity ... Mutation of Ser336 revealed that PKA could also stimulate GLI1 transcriptional activity ... Thus, our data demonstrate both negative and positive regulation of human GLI1 by PKA
Zeng et al., PloS one 2010 : We further show that activation of protein kinase A (PKA) efficiently inhibits ciliary localization of Gli2 and Gli3, but only moderately affects the ciliary localization of Gli1