UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to ITGB1

COL1A1 — ITGB1

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: CASP8 → Complex of COL1A1-ITGA2-ITGB1 (decreases, COL1A1/ITGA2/ITGB1 Activity)
Gendron et al., J Biol Chem 2003 *
Evidence: In experiments done in Jurkat T cells and activated peripheral blood T lymphocytes, engagement of alpha2beta1 integrin with collagen type I (Coll I) was found to significantly reduce Fas-induced apoptosis and caspase-8 activation
OpenBEL Selventa BEL large corpus: Complex of ITGA2-ITGB1 → COL1A1 (increases, COL1A1 Activity)
Evidence: Integrin alpha1-blocking and alpha2-blocking antibodies (Ab) each partially inhibited attachment of microvascular EC to collagen I, and alpha1-blocking Ab also inhibited attachment to collagen IV and laminin-1. Induction of alpha1beta1 and alpha2beta1 expression by VEGF promoted cell spreading on collagen I gels which was abolished by a combination of alpha1-blocking and alpha2-blocking Abs. In vivo, a combination of alpha1-blocking and alpha2-blocking Abs markedly inhibited VEGF-driven angiogen...
OpenBEL Selventa BEL large corpus: ITGB1 → COL1A1 (increases, COL1A1 Activity)
Evidence: These early stages paralleled collagen I activation of Src kinase and GTPase Rho through beta1 integrins.
KEGG Focal adhesion: CHAD/COL11A1/COL11A2/COL1A1/COL1A2/COL2A1/COL3A1/COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/COL5A1/COL5A2/COL5A3/COL6A1/COL6A2/COL6A3/COL6A6/COMP/FN1/IBSP/LAMA1/LAMA2/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/LAMB4/LAMC1/LAMC2/LAMC3/RELN/SPP1/THBS1/THBS2/THBS3/THBS4/TNC/TNN/TNR/TNXB/VTN/VWF → Complex of 21 proteins (protein-protein, activation)
KEGG ECM-receptor interaction: COL11A1/COL11A2/COL1A1/COL1A2/COL2A1/COL3A1/COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/COL5A1/COL5A2/COL5A3/COL6A1/COL6A2/COL6A3/COL6A6 → Complex of ITGA1-ITGB1 (protein-protein, activation)
KEGG ECM-receptor interaction: COL11A1/COL11A2/COL1A1/COL1A2/COL2A1/COL3A1/COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/COL5A1/COL5A2/COL5A3/COL6A1/COL6A2/COL6A3/COL6A6 → Complex of ITGA2-ITGB1 (protein-protein, activation)
KEGG ECM-receptor interaction: COL11A1/COL11A2/COL1A1/COL1A2/COL2A1/COL3A1/COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/COL5A1/COL5A2/COL5A3/COL6A1/COL6A2/COL6A3/COL6A6 → Complex of ITGA3-ITGB1 (protein-protein, activation)
KEGG ECM-receptor interaction: COL11A1/COL11A2/COL1A1/COL1A2/COL2A1/COL3A1/COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/COL5A1/COL5A2/COL5A3/COL6A1/COL6A2/COL6A3/COL6A6 → Complex of ITGA9-ITGB1 (protein-protein, activation)
KEGG ECM-receptor interaction: COL11A1/COL11A2/COL1A1/COL1A2/COL2A1/COL3A1/COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/COL5A1/COL5A2/COL5A3/COL6A1/COL6A2/COL6A3/COL6A6 → Complex of ITGA10-ITGB1 (protein-protein, activation)
KEGG ECM-receptor interaction: COL11A1/COL11A2/COL1A1/COL1A2/COL2A1/COL3A1/COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/COL5A1/COL5A2/COL5A3/COL6A1/COL6A2/COL6A3/COL6A6 → Complex of ITGA11-ITGB1 (protein-protein, activation)
NCI Pathway Database VEGFR3 signaling in lymphatic endothelium: alpha1/beta1 Integrin/Type I Collagen complex (ITGA1-ITGB1-COL1A1-COL1A2) → VEGFR3/VEGFD complex (FLT4-FIGF) (modification, collaborate)
Wang et al., J Biol Chem 2001
Evidence: mutant phenotype, assay
NCI Pathway Database VEGFR3 signaling in lymphatic endothelium: alpha1/beta1 Integrin/Type I Collagen complex (ITGA1-ITGB1-COL1A1-COL1A2) → VEGFR3/VEGFD/Type I Collagen/alpha1/beta1 Integrin complex (FIGF-FLT4-COL1A1-COL1A2-ITGA1-ITGB1) (modification, collaborate)
Wang et al., J Biol Chem 2001
Evidence: mutant phenotype, assay
NCI Pathway Database VEGFR3 signaling in lymphatic endothelium: VEGFR3/VEGFD complex (FLT4-FIGF) → VEGFR3/VEGFD/Type I Collagen/alpha1/beta1 Integrin complex (FIGF-FLT4-COL1A1-COL1A2-ITGA1-ITGB1) (modification, collaborate)
Wang et al., J Biol Chem 2001
Evidence: mutant phenotype, assay
NCI Pathway Database Beta1 integrin cell surface interactions: Type I Collagen/alpha2/beta1 Integrin complex (ITGA2-ITGB1-COL1A1-COL1A2) → Type I Collagen complex (COL1A1-COL1A2) (modification, collaborate)
Grzesiak et al., J Cell Biol 1992 *, Peng et al., J Immunol 2005, Vuoriluoto et al., Exp Cell Res 2008 *, Boisvert et al., Eur J Immunol 2010, Staatz et al., J Biol Chem 1990 *, Kramer et al., J Biol Chem 1989, Staatz et al., J Cell Biol 1989, Grzesiak et al., J Invest Dermatol 1995 *, Tuckwell et al., J Cell Sci 1995, Pfaff et al., Exp Cell Res 1993, Calderwood et al., J Biol Chem 1997
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: Type I Collagen/alpha2/beta1 Integrin complex (ITGA2-ITGB1-COL1A1-COL1A2) → alpha2/beta1 Integrin complex (ITGA2-ITGB1) (modification, collaborate)
Grzesiak et al., J Cell Biol 1992 *, Peng et al., J Immunol 2005, Vuoriluoto et al., Exp Cell Res 2008 *, Boisvert et al., Eur J Immunol 2010, Staatz et al., J Biol Chem 1990 *, Kramer et al., J Biol Chem 1989, Staatz et al., J Cell Biol 1989, Grzesiak et al., J Invest Dermatol 1995 *, Tuckwell et al., J Cell Sci 1995, Pfaff et al., Exp Cell Res 1993, Calderwood et al., J Biol Chem 1997
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: Type I Collagen complex (COL1A1-COL1A2) → alpha2/beta1 Integrin complex (ITGA2-ITGB1) (modification, collaborate)
Grzesiak et al., J Cell Biol 1992 *, Peng et al., J Immunol 2005, Vuoriluoto et al., Exp Cell Res 2008 *, Boisvert et al., Eur J Immunol 2010, Staatz et al., J Biol Chem 1990 *, Kramer et al., J Biol Chem 1989, Staatz et al., J Cell Biol 1989, Grzesiak et al., J Invest Dermatol 1995 *, Tuckwell et al., J Cell Sci 1995, Pfaff et al., Exp Cell Res 1993, Calderwood et al., J Biol Chem 1997
Evidence: physical interaction
NCI Pathway Database VEGFR3 signaling in lymphatic endothelium: VEGFR3/Type I Collagen/alpha2/beta1 Integrin complex (FLT4-COL1A1-COL1A2-ITGA2-ITGB1) → Type I Collagen/alpha2/beta1 Integrin complex (ITGA2-ITGB1-COL1A1-COL1A2) (modification, collaborate)
Wang et al., J Biol Chem 2001
Evidence: physical interaction
NCI Pathway Database VEGFR3 signaling in lymphatic endothelium: VEGFR3/Type I Collagen/alpha2/beta1 Integrin complex (FLT4-COL1A1-COL1A2-ITGA2-ITGB1) → VEGFR3 (FLT4) (modification, collaborate) Wang et al., J Biol Chem 2001
Evidence: physical interaction
NCI Pathway Database VEGFR3 signaling in lymphatic endothelium: Type I Collagen/alpha2/beta1 Integrin complex (ITGA2-ITGB1-COL1A1-COL1A2) → VEGFR3 (FLT4) (modification, collaborate) Wang et al., J Biol Chem 2001
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: alpha1/beta1 Integrin/Type I Collagen complex (ITGA1-ITGB1-COL1A1-COL1A2) → Type I Collagen complex (COL1A1-COL1A2) (modification, collaborate)
Tomaselli et al., Neuron 1990, Kramer et al., J Biol Chem 1989, Luque et al., FEBS Lett 1994 *, Pfaff et al., Exp Cell Res 1993, Calderwood et al., J Biol Chem 1997
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: alpha1/beta1 Integrin/Type I Collagen complex (ITGA1-ITGB1-COL1A1-COL1A2) → alpha1/beta1 Integrin complex (ITGA1-ITGB1) (modification, collaborate)
Tomaselli et al., Neuron 1990, Kramer et al., J Biol Chem 1989, Luque et al., FEBS Lett 1994 *, Pfaff et al., Exp Cell Res 1993, Calderwood et al., J Biol Chem 1997
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: Type I Collagen complex (COL1A1-COL1A2) → alpha1/beta1 Integrin complex (ITGA1-ITGB1) (modification, collaborate)
Tomaselli et al., Neuron 1990, Kramer et al., J Biol Chem 1989, Luque et al., FEBS Lett 1994 *, Pfaff et al., Exp Cell Res 1993, Calderwood et al., J Biol Chem 1997
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: alpha11/beta1 Integrin complex (ITGA11-ITGB1) → Type I Collagen complex (COL1A1-COL1A2) (modification, collaborate)
Velling et al., J Biol Chem 1999 *, Velling et al., J Biol Chem 2002, Zhang et al., J Biol Chem 2003 *
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: alpha11/beta1 Integrin complex (ITGA11-ITGB1) → alpha11/beta1 Integrin/Type I Collagen complex (ITGA11-ITGB1-COL1A1-COL1A2) (modification, collaborate)
Velling et al., J Biol Chem 1999 *, Velling et al., J Biol Chem 2002, Zhang et al., J Biol Chem 2003 *
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: Type I Collagen complex (COL1A1-COL1A2) → alpha11/beta1 Integrin/Type I Collagen complex (ITGA11-ITGB1-COL1A1-COL1A2) (modification, collaborate)
Velling et al., J Biol Chem 1999 *, Velling et al., J Biol Chem 2002, Zhang et al., J Biol Chem 2003 *
Evidence: physical interaction
NCI Pathway Database VEGFR3 signaling in lymphatic endothelium: VEGFR3/VEGFD/Type I Collagen/alpha2/beta1 Integrin complex (FIGF-FLT4-COL1A1-COL1A2-ITGA2-ITGB1) → Type I Collagen/alpha2/beta1 Integrin complex (ITGA2-ITGB1-COL1A1-COL1A2) (modification, collaborate)
Wang et al., J Biol Chem 2001
Evidence: mutant phenotype, assay
NCI Pathway Database VEGFR3 signaling in lymphatic endothelium: VEGFR3/VEGFD/Type I Collagen/alpha2/beta1 Integrin complex (FIGF-FLT4-COL1A1-COL1A2-ITGA2-ITGB1) → VEGFR3/VEGFD complex (FLT4-FIGF) (modification, collaborate)
Wang et al., J Biol Chem 2001
Evidence: mutant phenotype, assay
NCI Pathway Database VEGFR3 signaling in lymphatic endothelium: Type I Collagen/alpha2/beta1 Integrin complex (ITGA2-ITGB1-COL1A1-COL1A2) → VEGFR3/VEGFD complex (FLT4-FIGF) (modification, collaborate)
Wang et al., J Biol Chem 2001
Evidence: mutant phenotype, assay
NCI Pathway Database VEGFR3 signaling in lymphatic endothelium: VEGFR3/Type I Collagen/alpha1/beta1 Integrin complex (FLT4-COL1A1-COL1A2-ITGA1-ITGB1) → alpha1/beta1 Integrin/Type I Collagen complex (ITGA1-ITGB1-COL1A1-COL1A2) (modification, collaborate)
Wang et al., J Biol Chem 2001
Evidence: physical interaction
NCI Pathway Database VEGFR3 signaling in lymphatic endothelium: VEGFR3/Type I Collagen/alpha1/beta1 Integrin complex (FLT4-COL1A1-COL1A2-ITGA1-ITGB1) → VEGFR3 (FLT4) (modification, collaborate) Wang et al., J Biol Chem 2001
Evidence: physical interaction
NCI Pathway Database VEGFR3 signaling in lymphatic endothelium: alpha1/beta1 Integrin/Type I Collagen complex (ITGA1-ITGB1-COL1A1-COL1A2) → VEGFR3 (FLT4) (modification, collaborate) Wang et al., J Biol Chem 2001
Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: COL1A1 — ITGB1 (association, biochemical) Staatz et al., J Biol Chem 1990 *
MIPS CORUM ITGA11-ITGB1-COL1A1 complex: ITGA11-ITGB1-COL1A1 complex complex (COL1A1-ITGA11-ITGB1) Velling et al., J Biol Chem 1999 *
IRef Corum Interaction: Complex of COL1A1-ITGA11-COL1A1-ITGB1-ITGB1-ITGA11 (association, coimmunoprecipitation) Velling et al., J Biol Chem 1999 *