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CCNB1 — WEE1

Pathways - manually collected, often from reviews:

• BioCarta cell cycle: g2/m checkpoint: WEE1 → Cyclin B/CDC2 complex (CDC2-CCNB1) (modification, activates)
  
• NCI Pathway Database PLK1 signaling events: WEE1 (WEE1) → Cyclin B1/CDK1 complex (CCNB1-CDK1) (modification, activates)
  van Vugt et al., Mol Cell 2004*, McGowan et al., EMBO J 1993*
  Evidence: mutant phenotype, assay
• Reactome Reaction: CCNB1 → WEE1 (reaction) Parker et al., Science 1992*

Text-mined interactions from Literome

Putney et al., J Biol Chem 2003 : In the absence of ion translocation by NHE1, expression of cyclin B1 and the kinase activity of Cdc2 are decreased and Wee1 kinase expression increases
Gong et al., Int J Gynecol Cancer 2012 (Uterine Cervical Neoplasms) : Analyses of G2-checkpoint related proteins, the activation of Wee 1 and depression of cyclin B1 expression induced by radiation, could be restored to the control level by artemisinin