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IRF6 — SOCS1

Text-mined interactions from Literome

Crespo et al., Biochem J 2000 : However, LPS does not directly induce the synthesis of SOCS-1
Crespo et al., Eur J Immunol 2002 (MAP Kinase Signaling System) : These observations are mechanistically consistent with the known induction of suppressors of cytokine signaling (SOCS)-1 and SOCS-3 proteins by LPS ... The induction of SOCS-1 and SOCS-3 by LPS or IFN-beta ( an autocrine/paracrine mediator of LPS induced SOCS-1 mRNA synthesis ) occurs by way of multiple protein kinase pathways that include protein tyrosine kinases, protein kinase C, and mitogen activated protein kinases
Mostecki et al., J Biol Chem 2005 : The mechanisms regulating the transcription of SOCS-1 in response to LPS are not entirely understood ... Chromatin immunoprecipitation experiments confirm LPS induced binding of Egr-1 to the SOCS-1 promoter in vivo ... Additionally, Egr-1 ( -/- ) macrophages show reduced levels of LPS induced SOCS-1 expression in comparison with macrophages derived from Egr-1 ( +/+ ) littermate controls
Tanimoto et al., Circ J 2005 (Ventricular Dysfunction, Left) : To determine whether SOCS1 expression in cardiomyocytes is sufficient to inhibit LPS- and cytokine induced expression of iNOS mRNA, the effects of forced expression of SOCS1 in cultured neonatal cardiomyocytes were investigated using an adenovirus mediated transfection system
Scott et al., Hepatology 2009 : Similarly, inhibition of SOCS1 using small interfering ( si ) RNA mediated knockdown prevented LPS desensitization in hepatocytes
Sun et al., Immunol Lett 2012 : Furthermore, we demonstrated that progesterone up-regulated LPS induced SOCS1 expression while overexpression of miR-155 inhibited SOCS1 expression