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POT1 — RPA1

Text-mined interactions from Literome

Barrientos et al., Mol Cell Biol 2008 : Mechanistically, binding of POT1 to telomeric ssDNA and association with TPP1 inhibit the localization of RPA , which can function as a DNA damage sensor, to telomeres
Gong et al., Mol Cell 2010 : In S/G2, RPA was readily detectable at dysfunctional telomeres, and both POT1a and POT1b were required to exclude RPA and prevent ATR activation
Takai et al., Mol Cell 2011 : POT1a blocks the binding of RPA to telomeres, suggesting that ATR is repressed through RPA exclusion
Flynn et al., Cell cycle (Georgetown, Tex.) 2012 : Loss of POT1 leads to aberrant accumulation of RPA at telomeres and activation of the ataxia telangiectasia and Rad3 related kinase ( ATR ) -mediated checkpoint response, suggesting that POT1 antagonizes RPA binding to telomeric ssDNA