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PTEN — STAT3
Text-mined interactions from Literome
Sun et al., J Gen Virol 2002
(Laryngeal Neoplasms...) :
These data indicate that
PTEN negatively
regulates STAT3 activation in HPV infected papilloma cells
Iliopoulos et al., Mol Cell 2010
(Adenocarcinoma...) :
STAT3 activation of miR-21 and miR-181b-1 via
PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer
Ke et al., J Hepatol 2012
(Disease Models, Animal...) :
Parallel in vitro studies with bone marrow derived-macrophages have confirmed that
HO-1-STAT3 axis induced PI3K/Akt negatively
regulated PTEN expression in TLR4 dependent fashion
Jung et al., Oncogene 2013
(Carcinoma, Non-Small-Cell Lung...) :
Pharmacological inhibition of phosphatidyl inositol 3-kinase or transfection with wild-type PTEN suppressed phosphorylation of Akt, mTOR and
STAT3 ( Y705 ), sphere formation, and CXCR4 expression in A549/GR cells, whereas mutant
PTEN enhanced these events
Cai et al., Basic Res Cardiol 2012
(Myocardial Reperfusion Injury) :
In the gastrocnemius muscle, RIPC resulted in immediate inactivation of the phosphatase
PTEN and
activation of
Stat3 , with increased IL-10 expression 24 h later