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PTEN — PTK2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PTK2 → PTEN (decreases, PTEN Activity, PTK2 Activity)
  Evidence: The tumor suppressor PTEN dephosphorylates focal adhesion kinase (FAK) and inhibits integrin-mediated cell spreading and cell migration
• OpenBEL Selventa BEL large corpus: PTK2 → PTEN (decreases, PTK2 Activity)
  Evidence: The tumor suppressor PTEN dephosphorylates focal adhesion kinase (FAK) and inhibits integrin-mediated cell spreading and cell migration
• OpenBEL Selventa BEL large corpus: PTK2 → PTEN (decreases, PTK2 Activity) Haier et al., Oncogene 2002*
  Evidence: Using preparations of native FAK and PTEN from HT-29 cells in a specific Tyr-phosphatase assay FAK was identified as substrate for this dephosphorylation.
• BioCarta pten dependent cell cycle arrest and apoptosis: pten, mmac1 (PTEN) → FAK (PTK2) (modification, activates)
• KEGG Focal adhesion: PTEN → PTK2 (protein-protein, inhibition)
• WikiPathways Focal Adhesion: PTEN → PTK2 (inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PTEN — PTK2 (physical association, affinity chromatography technology) Tamura et al., J Biol Chem 1999*
• IRef Biogrid Interaction: PTEN — PTK2 (physical association, affinity chromatography technology) Haier et al., Oncogene 2002*
• IRef Biogrid Interaction: PTEN — PTK2 (physical association, affinity chromatography technology) Crockett et al., Proteomics 2005
• IRef Intact Interaction: PTEN — PTK2 (physical association, proximity ligation assay) Liu et al., Mol Cell Proteomics 2013
• IRef Ophid Interaction: PTEN — PTK2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• STRING interaction: PTK2 — PTEN (interaction, mapped from kegg_pathways)
• STRING interaction: PTEN — PTK2 (interaction, mapped from kegg_pathways)