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MMP9 — PTEN
Text-mined interactions from Literome
Park et al., Cancer Res 2002
(Glioblastoma...) :
Ectopic expressions of adenoviral ( Ad ) -wt-PTEN and -lipid phosphatase-deficient ( G129E )
-PTEN , but not both protein and -lipid phosphatase-deficient ( C124S ) -PTEN,
reduced MMP-9 secretion and invasion by HA ... These findings strongly suggest the possibility that
PTEN may
block HA-induced
MMP-9 secretion and invasion through its protein phosphatase activity
Moon et al., Arch Biochem Biophys 2004
:
PTEN induces G1 cell cycle arrest and
inhibits MMP-9 expression via the regulation of NF-kappaB and AP-1 in vascular smooth muscle cells ... Expression of
PTEN also
led to the inhibition of TNF-alpha induced
matrix metalloproteinase-9 (MMP-9) expression in VSMC as determined by zymography and immunoblot
Furukawa et al., Int J Oncol 2006
(Brain Neoplasms...) :
Ad5CMV-PTEN transfer into the glioma cell lines lacking the wild-type gene product decreased the levels of matrix metalloproteinase (MMP)-2 mRNA and
inhibited the enzymatic activities of MMP-2 and
MMP-9
Tian et al., Oncol Rep 2010
(Carcinoma, Hepatocellular...) :
On the molecular level, overexpression of
PTEN suppressed expression of
matrix metalloproteinase (MMP)-2 and -9 in HepG2 cells
Chen et al., Nan Fang Yi Ke Da Xue Xue Bao 2013
:
MMP-2/MMP-9 inhibitor III did not obviously
affected the expression of
PTEN , VEGF or Flk-1 as compared with the non transfected or empty vector transfected cells