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IFI27 — PTEN

Text-mined interactions from Literome

Mamillapalli et al., Curr Biol 2001 : PTEN regulates the ubiquitin dependent degradation of the CDK inhibitor p27 ( KIP1 ) through the ubiquitin E3 ligase SCF ( SKP2 ) ... We have shown previously that PTEN negatively controls the G1/S cell cycle transition and regulates the levels of p27 ( KIP1 ), a CDK inhibitor [ 3, 4 ] ... We found that ectopic expression of SKP2 alone is sufficient to reverse PTEN induced p27 accumulation, restore the kinase activity of cyclin E/CDK2, and partially overcome the PTEN induced G1 cell cycle arrest
Zhu et al., Cancer Res 2001 (Adenocarcinoma...) : Although PTEN signaling directly regulates p27 ( KIP1 ) levels in some settings, in endometrial carcinoma cells, PTEN expression indirectly regulated p27 ( KIP1 ) activity by modulating levels of cyclin D3
Liu et al., Am J Pathol 2002 (Carcinoma...) : Transfection of PTEN resulted in p27 accumulation and was partially additive to the effect of VD/EB1089
Jonason et al., Cell cycle (Georgetown, Tex.) 2007 : Here, we show that PTEN negatively regulates expression of cyclin D1 and that cyclin D1 plays a unique role in p27 proteolysis
Ma et al., Mol Cell Biol 2008 : In PTEN silenced HEK 293 cells and PTEN-deficient human glioblastoma U87MG cells, the effect of CSIG on p27 ( Kip1 ) expression and cell division was abolished, suggesting that PTEN was required for the role of CSIG on p27 ( Kip1 ) regulation and cell cycle progression