Gene interactions and pathways from curated databases and text-mining

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JUN — TGFB1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Wong et al., Mol Cell Biol 1999 : Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta
Seppänen et al., Oncol Res 1998 (Adenocarcinoma...) : In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro ... In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Imai et al., Infect Immun 2000 : Since TGF-beta1 pretreatment inhibited LPS stimulated expression of c-fos and c-jun genes and also the binding of nuclear proteins to the consensus sequence of the binding site for activation protein 1 (AP-1), a heterodimer of c-Fos and c-Jun, in the cells, TGF-beta1 inhibition of CD14 expression may be a consequence of downregulation of AP-1
Finlay et al., J Biol Chem 2000 : Transforming growth factor-beta 1-induced activation of the ERK pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factor ... Dependence of ERK/AP-1 activation on bFGF induction was demonstrated by inhibition of TGF-beta1 induced ERK/AP-1 activation when conditioned medium from TGF-beta1 treated cells was incubated with bFGF neutralizing antibody
Dennler et al., J Biol Chem 2000 : c-Jun inhibits transforming growth factor beta mediated transcription by repressing Smad3 transcriptional activity
Junn et al., J Immunol 2000 : NAC also reduced TGF-beta1 induced AP-1 binding activity, which is involved in IL-6 gene expression
Palcy et al., J Bone Miner Res 2000 : Protein kinase C ( PKC ) - and protein tyrosine kinase ( PTK ) -dependent pathways have been implicated in both TGF-beta1 signaling and AP-1 gene regulation
Rodríguez-Barbero et al., FEBS Lett 2002 : TGF-beta1 induced p38 and extracellular signal regulated kinase ( ERK ) 1/2 phosphorylation whereas no effect on Jun N-terminal kinase phosphorylation was observed
Samson et al., Surgery 2002 : TGF-beta1 also induces c-Jun , a potential proapoptotic transcription factor ... These data demonstrate that TGF-beta1 induces c-Jun , but c-Jun is not proapoptotic in hepatocytes
Zhou et al., Zhonghua Yi Xue Za Zhi 2002 : To clarify whether the activating protein-1 (AP-1) is involved in the transcriptional regulation of expression of oxidized low density lipoprotein ( Ox-LDL ) induced transforming growth factor (TGF)-beta(1) gene and further to investigate the possible signal transduction pathway in the cultured mesangial cells ( MsCs )
Arsura et al., Oncogene 2003 (Carcinoma, Hepatocellular...) : Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis : implications in liver tumor formation
Bamba et al., Am J Physiol Gastrointest Liver Physiol 2003 : The EMSAs demonstrated that both IL-1beta and TGF-beta1 induced AP-1 activation within 2 h after stimulation, and a blockade of AP-1 activation by the recombinant adenovirus containing a dominant negative c-Jun markedly reduced the IL-1beta- and TGF-beta1 induced IL-11 mRNA expression
Utsugi et al., Am J Respir Cell Mol Biol 2003 : TGF-beta1 activated c-Jun NH2-terminal kinase (JNK) and p38 MAP kinase, but not ERK in HFL-1 cells
Park et al., Oncogene 2003 (Prostatic Neoplasms) : TGF-beta1 activated c-Jun phosphorylation, and IL-6 induction by TGF-beta1 was severely impeded by DN-c-Jun and DN-JNK or AP-1 inhibitor curcumin, showing that the JNK-c-Jun-AP-1 signaling plays a pivotal role in TGF-beta1 stimulation of IL-6 ... It was also found that the Ras-Raf-MEK1 cascade is activated by TGF-beta1 and participates in the TGF-beta1 induction of IL-6 in an AP-1 dependent manner
Wang et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2001 : Heat shock induces elevated expression of hsp, c-Jun , CLK-1 gene while decreases expression of integrin alpha-4 and transforming growth factor beta
Luettich et al., Molecular cancer 2003 (MAP Kinase Signaling System) : TGFbeta1 activates c-Jun and Erk1 via alphaVbeta6 integrin ... We conclude that TGFbeta1 activates c-Jun via the MEKK1/p38 MAP kinase pathway and influences cytoskeletal organization
Naso et al., J Invest Dermatol 2003 : These analyses demonstrated that transforming growth factor beta1 stimulation of Col7a1 transcription is dependent on a putative interaction between Smads and AP1
Baroni et al., J Cutan Pathol 2004 (Psoriasis) : We found that M. furfur up-regulates transforming growth factor-beta1 ( TGF-beta1 ), integrin chain, and HSP70 expression in human keratinocytes via AP-1 dependent mechanism
Guo et al., Diabetes 2004 : PPAR-gamma overexpression inhibited TGF-beta 1-induced fibronectin expression as well as the activation of AP-1 ... 15-Deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) ( 15d-PGJ ( 2 ) ), a natural PPAR-gamma ligand, also inhibited TGF-beta1 induced fibronectin expression by suppressing AP-1 activation by TGF-beta 1 ... In conclusion, pioglitazone inhibits TGF-beta 1-induced fibronectin expression by inhibiting AP-1 activation dependent on PPAR-gamma, while 15d-PGJ ( 2 ) acts through a dual mechanism independent of and dependent on PPAR-gamma activation in mouse mesangial cells
Kim et al., Invest Ophthalmol Vis Sci 2005 : To evaluate the effects of TGF-beta1 and doxycycline on production of gelatinase MMP-9 and activation of Smad, c-Jun N-terminal kinase (JNK) , extracellular regulated kinase (ERK), and p38 mitogen activated protein kinase ( MAPK ) signaling pathways in human corneal epithelial cells
Stanley et al., Biochem Biophys Res Commun 2005 (Neovascularization, Pathologic...) : These effects are caused by the inhibition of constitutively active AP-1 in prostate cancer cells, resulting in the down-regulation of secretion of VEGF and TGF-beta1 from PC-3 cells
Kaur et al., J Biol Chem 2005 (Carcinoma, Hepatocellular) : X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 ( JNK1 ) activation by transforming growth factor beta1 ( TGF-beta1 ) through ubiquitin mediated proteosomal degradation of the TGF-beta1 activated kinase 1 (TAK1)
Lee et al., J Immunol 2006 : Our results suggest that IL-1beta stimulated transcription of TGF-beta1 is temporally regulated by NF-kappaB and AP-1 and involves histone hyperacetylation at distinct promoter sites
Chiarpotto et al., Biofactors 2005 (Fibrosis) : Moreover, we demonstrate that HNE can indeed contribute to the onset of fibrosis by stimulating AP-1 binding to DNA and consequently inducing TGFbeta1 expression, since thiol-group reagents, such as N-ethylmaleimide and 4- ( chloro-mercuri ) -benzenesulfonic acid, that down-modulate HNE entrance and localisation inside the cell, prevent both phenomena
Harding et al., Kidney Int 2006 : TGFbeta1 increased transcription by approximately 50 % and activated both AP-1 and NF-kappaB
Hu et al., Lung 2006 : In addition, dominant negative mutant c-Jun ( TAM67 ) downregulated TGF-beta1 induced AP-1 transactivation and alpha-SMA expression ... In additional, PD98059 but not SB203580 inhibited the AP-1 DNA binding activity induced by TGF-beta1
Santibañez et al., FEBS Lett 2006 (Cell Transformation, Neoplastic) : TGF-beta1 induces JNK phosphorylation, c-Jun transactivation and AP1 activation
Zhang et al., Am J Pathol 2006 : Furthermore, Smad3 blockade specifically inhibited activation of the transcription factor AP-1 by TGF-beta1 , whereas PD98059 prevented TGF-beta1 dependent nuclear factor-kappaB activation
Dhandapani et al., J Neurosci Res 2007 (Brain Neoplasms...) : Induction of transforming growth factor-beta1 by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is mediated by MEK/ERK signaling and AP-1 activation
Lai et al., Int J Dermatol 2007 : The cellular morphology, mitogenic activities, expression of keratinocyte growth factor (KGF) and transforming growth factor beta-1 ( TGF-beta1 ), and activation of extracellular regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling pathways of dermal fibroblasts were studied after ultrasound treatment
Matsuzaki et al., Hepatology 2007 (Carcinoma, Hepatocellular...) : Conversely, transforming growth factor beta ( TGF-beta ) activates not only TGF-beta type I receptor ( TbetaRI ) but also c-Jun N-terminal kinase (JNK) , which convert the mediator Smad3 into two distinctive phosphoisoforms : C-terminally phosphorylated Smad3 ( pSmad3C ) and linker phosphorylated Smad3 ( pSmad3L )
Li et al., Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2008 : To study the role of activator protein-1 (AP-1) in the up-regulation expression of tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 ( TGF-beta(1) ) in silica stimulated macrophage cells ( RAW264.7 )
Fichtner-Feigl et al., Cancer Res 2008 (Carcinoma...) : Here, we show that in two tumor models ( the CT-26 metastatic colon cancer and the 15-12RM fibrosarcoma regressor models ), this counter-surveillance mechanism requires the expression of a novel IL-13 receptor, IL-13R alpha(2), on Gr-1 ( intermediate ) cells, because down-regulation of IL-13R alpha(2) expression or the activator protein-1 signal generated by the receptor via in vivo administration of specific small interfering RNA or decoy oligonucleotides leads to loss of TGF-beta(1) production
Seppänen et al., Acta Obstet Gynecol Scand 2008 (Carcinoma, Endometrioid...) : We were able to show that IFN-gamma, TGF-beta(1) and TNF-alpha all increased the binding activity of transcription factor AP-1 ( AP-1 )
Lee et al., Oncogene 2009 : A promoter deletion analysis suggested that activating protein 1 (AP-1) plays a role in TGFbeta1 gene transactivation, which was corroborated by the observation that a deficiency of the G-proteins decreased the AP-1 activity, whereas their activation enhanced it
Han et al., J Korean Med Sci 2009 (MAP Kinase Signaling System) : Aldosterone induced TGF-beta1 expression is regulated by mitogen activated protein kinases and activator protein-1 in mesangial cells ... We examined the role of extracellular-signal regulated kinase 1 and 2 ( ERK1/2 ), c-Jun N-terminal kinase (JNK) and activator protein-1 (AP-1) in the aldosterone induced TGF-beta(1) expression in rat mesangial cells ... We examined the role of extracellular-signal regulated kinase 1 and 2 ( ERK1/2 ), c-Jun N-terminal kinase (JNK) and activator protein-1 (AP-1) in the aldosterone induced TGF-beta(1) expression in rat mesangial cells
Wu et al., J Am Soc Nephrol 2009 (Diabetes Mellitus, Experimental...) : Finally, pharmacologic and dominant negative inhibition of EGFR blocked glucose induced activation of PKC-beta1, phosphorylation of AktS473, activation of AP-1 , and upregulation of TGF-beta1
Geismann et al., Cancer Res 2009 (Adenocarcinoma...) : Both TGF-beta1- and PMF induced L1CAM expression were independent of Smad proteins but required c-Jun NH ( 2 ) -terminal kinase activation leading to the induction of the transcription factor Slug
Shi et al., Sichuan Da Xue Xue Bao Yi Xue Ban 2009 : To investigate the expression of CTGF, CTGF mRNA, NF-kappaB and AP-1 induced by TGF-beta1 in human lung fibroblast ( HLF-02 ), and study the effect and possible mechanism of rosiglitazone on signal pathways of TGF-beta1 in HLF-02 ... The effects of TGF-beta1 , curcumin, PDTC and rosiglitazone on the expression of CTGF, NF-kappaB and AP-1 were evaluated with Western blot
Markovics et al., J Biol Chem 2010 (Inflammation) : Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1 , and the p38 pathway
Uría et al., J Biol Chem 1998 : Finally, by using electrophoretic mobility shift assays and antibody supershift analysis, we propose that c-Fos, c-Jun , and JunD may play major roles in the collagenase-3 activation by TGF-beta1 in human fibroblasts
Han et al., J Pharmacol Exp Ther 1998 : Under identical condition, we examined the effect of TGF-beta1 on the activity of nuclear factor AT ( NF-AT ), nuclear factor kappaB (NF-kappaB), activator protein-1 (AP-1) and octamer, all of which contribute to the regulation of IL-2 gene expression ... Electrophoretic mobility shift assays showed that TGF-beta1 markedly increased NF-AT, NF-kappaB and AP-1 binding to their respective cognate DNA binding sites, whereas octamer binding remained constant, as compared with untreated cells