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FAS — TGFB1
Text-mined interactions from Literome
Tanaka et al., J Reprod Immunol 2000
:
Flow cytometric analyses demonstrated that
TGF-beta1 , IL-1beta, and EGF did not
induce Fas expression on the cell surface
Yuen et al., Cancer 2001
(Carcinoma, Hepatocellular...) :
The
role of
transforming growth factor beta 1 ( TGF-beta1 ) in modulating the expression of
Fas by CTLs is not known in HCC
Kim et al., Mol Biol Cell 2004
(Carcinoma...) :
We showed that
TGF-beta 1 induced the expression and activation of
Fas and the subsequent caspase-8 mediated Bid cleavage ... Interestingly, expression of dominant negative FADD and treatment with caspase-8 inhibitor efficiently prevented TGF-beta 1-induced apoptosis, whereas the treatment with an activating CH11 or a neutralizing ZB4 anti-Fas antibody, recombinant Fas ligand, or Fas-Fc chimera did not affect activation of
Fas and the subsequent
induction of apoptosis by
TGF-beta 1
Jung et al., Int J Mol Med 2004
(Leukemia...) :
Second,
TGF-beta1 up-regulated
Fas signaling pathway inhibitor cFLIPL to block the pro-caspase-8 cleavage and thus promoted survival of leukaemia/lymphoma cells
Sharma et al., Am J Obstet Gynecol 2009
(Ovarian Neoplasms) :
OM-3FAs increased the level of
TGF-beta1 , Smad-3, and p21 protein in ovarian cancer cells known to be more sensitive to their inhibitory effect
Tanaka et al., Horm Metab Res 1998
:
Flow cytometric analyses showed that
TGF-beta 1 did not
affect Fas expression on the cell surface
Genestier et al., J Exp Med 1999
:
This decrease was associated with inhibition of Fas ( Apo-1/CD95) ligand (FasL ) expression, whereas
Fas signaling was not
affected by
TGF-beta1