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ADCY4 — PGD

Text-mined interactions from Literome

Goh et al., Exp Eye Res 1990 : PGD2 dose-dependently activated the adenylate cyclase with a maximal activity increase of about 60 %
Trist et al., Br J Pharmacol 1989 : The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclase
Henry et al., Eur J Biochem 1987 : Studies of the interaction of 9-HODE with activation of platelet adenylate cyclase activity mediated by prostaglandin E1 ( PGE1 ) and prostaglandin D2 (PGD2) indicated that this fatty acid produced a parallel shift in the concentration/response curve of PGE1 and PGD2 without altering maximal response, which was substantially greater than that observed with 9-HODE alone
Cooper et al., Prostaglandins 1979 : Incubating platelets with 5 x 10 ( -5 ) M PGD2 for 2 hr resulted in a 45 % decrease in PGD2 activation of adenylate cyclase and a 25 % decrease in stimulation by PGE1
Horne et al., Prostaglandins Leukot Med 1984 : Desacetyl-1-nantradol, the active form of the drug, blocked the binding of prostaglandin D2 to platelets and the PGD2 induced stimulation of adenylate cyclase activity, but had no effect on the interaction of prostaglandin E1 with platelets
Higashida et al., Brain Res 1984 (Glioma...) : PGD2 ( 10 ( -4 ) M ) produced a 3-fold increase of adenylate cyclase activity in NG108-15 cell homogenates through its receptors that are distinct from those of PGE1 and PGI2
Heim et al., J Physiol Pharmacol 1994 : PGF2 alpha, PGD2 , the stable prostacyclin analogue iloprost and the thromboxane-mimetic U46619 had no significant effects on adenylate cyclase activity and [ Ca2+ ] i. Histamine ( 10 microM ) stimulated adenylate cyclase activity to 236 % of control value, an effect which could be blocked by the H2-receptor antagonist ranitidine